| 尹承华,毕大鹏,杜敏.通心络胶囊对阿司匹林抵抗患者血小板聚集的影响[J].,2010,30(4):380-382 |
| 通心络胶囊对阿司匹林抵抗患者血小板聚集的影响 |
| Effect of Tongxinluo Capsule on Platelet Aggregation Function in Patients with Aspirin Resistance |
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| DOI： |
| 中文关键词: 冠心病 阿司匹林抵抗 通心络胶囊 血小板聚集 |
| 英文关键词:coronary heart disease aspirin resistance Tongxinluo Capsule platelet aggregation |
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| 中文摘要: |
| 目的探讨通心络胶囊对阿司匹林抵抗(aspirin resistance,AR)的冠心病患者血小板聚集的影响。方法选择正规服用阿司匹林(100 mg/d)超过1个月的冠心病患者330例,分别用胶原(collagen,COL)和二磷酸腺苷(adenosine diphosphate,ADP)作为诱导剂测定其静脉血中血小板聚集值,根据结果筛选出AR患者,随机分为3组。联合治疗组:服用通心络胶囊,每次3粒,1天3次,并加服阿司匹林,100 mg/d;通心络组:服用通心络胶囊,每次3粒,1天3次;阿司匹林组:继续服用阿司匹林,100 mg/d。疗程均为1个月。检测治疗前及治疗1个月后的血小板聚集值。结果330例患者中89例存在阿司匹林抵抗,占26.97%。联合治疗组与通心络组服药1个月后血小板聚集值较治疗前均明显下降,差异有统计学意义(P<0.05),阿司匹林组较治疗前无明显改变。治疗后联合治疗组、通心络组的血小板聚集值与阿司匹林组比较均有统计学意义(P<0.05)。结论通心络胶囊对ADP和COL诱导血小板聚集值有一定的降低作用。 |
| 英文摘要: |
| Objective To investigate the effect of Tongxinluo Capsule(TXLC) on platelet aggregation in patients of coronary heart disease(CHD) with aspirin resistance(AR).Methods Patients with AR were screened out from 330 CHD patients,who had regularly taken aspirin(100 mg/d) for more than one month,by testing platelet aggregation level after adenosine diphosphate(ADP) and collagen(COL) induction.They were randomly assigned to three groups: the combined treatment group treated by TXLC+aspirin,the TXL group treated by TXLC alone and the AS group treated by aspirin alone,at the dose of TXLC 3 capsules thrice a day,and that of aspirin 100 mg/d.The therapeutic course for all was one month.Patients′ platelet aggregation was measured before and after 1-month treatment.Results Eighty-nine patients with AR were screened out from the 330 CHD patients,the occurrence rate being 26.97%.Platelet aggregation was significantly decreased after 1-month treatment in the combined treatment group and the TXL groups(P<0.05),but changed insignificantly in the AS group,the difference between the former two and the latter group was statistically significant(P<0.05).Conclusion TXLC has definite effect in reducing the ADP+COL induced platelet aggregation. |
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