| 郭登洲,边东,王月华,陈志强,韩培英,商亚茹.肾炎宁治疗非肾病综合征IgA肾病的疗效观察[J].,2010,30(8):841-844 |
| 肾炎宁治疗非肾病综合征IgA肾病的疗效观察 |
| Effect of Treatment of Non-nephrotic Syndrome IgA Nephropathy with Shenyanning |
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| DOI： |
| 中文关键词: 肾炎宁 IgA肾病 中医药治疗 |
| 英文关键词:Shenyanning IgA nephropathy traditional Chinese medical treatment |
| 基金项目:河北省科技攻关计划项目(No.00276205D,092061106D) |
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| 中文摘要: |
| 目的观察肾炎宁对非肾病综合征IgA肾病的治疗效果。方法将70例已确诊的原发性IgA肾病患者随机分为肾炎宁治疗组35例和氯沙坦治疗组35例,分别给予肾炎宁中药汤剂每日1剂和氯沙坦50mg/d口服,疗程为1年,观察疗效、中医证候积分、尿红细胞计数、内生肌酐清除率、24h尿蛋白定量、终点事件发生率。结果治疗组总有效率为77.1%,对照组为54.3%,两组比较,差异有统计学意义(P<0.05);治疗组治疗后中医证候积分较治疗前和对照组治疗后明显下降(P<0.05或P<0.01);治疗组治疗后在减少蛋白尿和血尿方面与治疗前和对照组治疗后比较,差异均有统计学意义(P<0.05或P<0.01);两组治疗后与治疗前比较内生肌酐清除率差异无统计学意义;治疗组的终点事件发生率低于对照组,但差异无统计学意义。结论肾炎宁治疗IgA肾病明显优于单纯西药治疗。 |
| 英文摘要: |
| Objective To observe the curative effect of Shenyanning(SYN) on non-nephrotic syndrome IgA nephropathy(IgAN) .Methods Seventy primary IgAN patients were equally randomized into two groups,the treatment group and the control group,they were orally treated with SYN Decoction(one dose per day) and Losartan(50 mg per day) respectively for 1 year.Efficacy of treatment,Chinese medicine syndrome scores,end-point events occurrence as well as changes of related laboratory indices were observed.Results The total effective rate in the treatment group was obviously higher than that in the control group(77.1% vs.54.3%,P < 0.05) .After treatment,the Chinese medicine syndrome scores,urinary protein and urinary red-cell count reduced significantly in the treatment group(P <0.05 or P <0.01) and showed significant difference as compared with those in the control group(P <0.05 or P <0.01);while the endogenous creatinine clearance was changed insignificantly in both groups.Beside,the occurrence of end-point events in the treatment group was slightly lower than that in the control group,though showed no statistical difference between them.Conclusion The curative effect of SYN in treating IgAN was obviously better than that of simple Western medicine. |
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