| 徐天朝,苏晶,王伟宁,陈国良,刘烨华,郑革,赵安晶,李娜.针刺三步疗法配合小剂量抗精神病药治疗首发精神分裂症临床研究[J].,2010,30(11):1138-1141 |
| 针刺三步疗法配合小剂量抗精神病药治疗首发精神分裂症临床研究 |
| Effect of Three-step Acupuncture Combined with Small Dosage Antipsychotic in Treating Incipient Schizophrenia |
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| DOI： |
| 中文关键词: 精神分裂症 针灸疗法 中西医结合治疗 |
| 英文关键词:schizophrenia acupuncture therapy integrative medical therapy |
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| 中文摘要: |
| 目的探讨针刺三步疗法配合小剂量抗精神病药物治疗首发精神分裂症的疗效和安全性。方法 60例首发精神分裂症患者随机分为研究组和对照组,每组30例。研究组采用针刺三步疗法配合小剂量抗精神病药物治疗,对照组采用足量抗精神病药物治疗,疗程8周。采用阳性阴性症状量表(PANSS)评价临床疗效,副反应量表(TESS)评价不良反应。结果两组8周时临床疗效比较差异无统计学意义(P>0.05);但第2、4周时PANSS总分研究组(74.26±9.54,56.33±10.12)优于对照组(85.56±9.73,70.57±9.62,P<0.05);TESS量表结果表明在神经系统、植物神经系统的不良反应方面,研究组优于对照组(P<0.05)。结论针刺三步疗法配合小剂量抗精神病药治疗首发精神分裂症与单纯使用抗精神病药物相比疗效相当,起效快,且不良反应少。 |
| 英文摘要: |
| Objective To explore the clinical efficacy and safety of three-step acupuncture(TSA) combined with small dosage antipsychotic in treating incipient schizophrenia(IS).Methods Sixty IS patients were randomly assigned to the test group and the control group equally.Patients in the test group received the combined therapy of TSA and antipsychotic,while patients in the control group were treated by full-dose antipsychotic,all for 8 weeks.The clinical efficacy was assessed by the positive and negative syndrome scale(PANSS),and the adverse reaction was evaluated by treatment emergent symptom scale(TESS).Results The clinical efficacy in the two groups showed insignificant difference at the end of the 8-week treatment(P>0.05),but the total scores of PANSS evaluated at the end of the 2nd and 4th week in the test group(74.26±9.54,56.33±10.12) were significantly higher than those in the control group(85.56±9.73,70.57±9.62),respectively(P<0.05),furthermore,TESS analysis showed that the incidence of adverse reactions in nervous system and autonomic nervous system in the test group were also lesser than in the control group(P<0.05).Conclusion The combined therapy of TSA and small dose antipsychotic shows an efficacy equivalent to that of full-dose antipsychotic,but with shorter initiation time and less side effects. |
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