| 方美凤,谭峰,张炘,刘晓林,王学文.化痰通络颗粒对脑梗死患者外周血细胞因子信号转导抑制因子-3及肿瘤坏死因子-α的影响[J].,2010,30(11):1142-1145 |
| 化痰通络颗粒对脑梗死患者外周血细胞因子信号转导抑制因子-3及肿瘤坏死因子-α的影响 |
| Effects of Huatan Tongluo Granule on SOCS-3 and TNF-α Expressions in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 急性脑梗死 风痰瘀阻型 外周血细胞信号转导抑制因子-3 肿瘤坏死因子-α 化痰通络颗粒 |
| 英文关键词:acute cerebral infarction phlegm-wind-stasis obstruction type suppressors of cytokine signaling-3 tumor necrosis factor-alpha Huatan Tongluo Granule |
| 基金项目:广东省卫生厅基金资助项目(No.01JJY2037);国家重点基础研究发展计划分项目(No.2003CB517102) |
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| 中文摘要: |
| 目的观察化痰通络颗粒对风痰瘀阻型急性脑梗死(ACI)患者外周血细胞因子信号转导抑制因子-3(SOCS-3)及肿瘤坏死因子-α(TNF-α)表达的影响。方法 66例发病72 h内的风痰瘀阻型ACI患者随机分为两组,治疗组34例口服化痰通络颗粒加基础治疗,对照组32例仅基础治疗;用酶联免疫分析法(ELISA)测定两组ACI患者治疗前及治疗后第3、7天血清SOCS-3水平,用化学发光法检测两组治疗前及治疗后第7天血清TNF-α水平,并与20名健康人作比较,同时用Barthel指数、NIHSS评分法评价两组治疗前及治疗后第7、14、21天神经功能缺损程度的变化。结果两组患者治疗前及治疗后第3、7天血清SOCS-3、治疗前及治疗后第7天TNF-α水平均显著高于健康人组(P<0.05)。治疗第7天时治疗组SOCS-3水平(ng/L,360.98±123.31)高于对照组(281.87±133.66,P<0.05),TNF-α水平(ng/L,35.72±19.94)低于对照组(49.86±34.79,P<0.05);治疗第7、14天时治疗组NIHSS评分低于对照组(P<0.05),Barthel指数评分治疗组治疗后第14、21天高于对照组(P<0.05)。结论化痰通络颗粒促进风痰瘀阻型ACI患者神经功能恢复的作用可能与上调炎症抑制因子SOCS-3与下调促炎因子TNF-α水平,减轻脑缺血继发的炎症损伤等机制密切相关。 |
| 英文摘要: |
| Objective To observe the effect of Huatan Tongluo Granule(HTG) on the expression of suppressors of cytokine signaling-3(SOCS-3) and tumor necrosis factor-alpha(TNF-α) in patients with acute cerebral infarction(ACI) of phlegm-wind-stasis obstruction(PWSO) syndrome type.Methods Sixty-six ACI patients of PWSO type admitted within 72 h were randomized into the treatment group(34 cases) and the control group(32 cases),they were treated with foundational therapeutics,but HTG was given additionally to patients in the treatment group.SOCS-3 expression was detected by ELISA before treatment(d0) and on the 3rd(d3) and 7th day(d7) of treatment;TNF-α expression was detected by chemiluminescence at d0 and d7.Data were compared with the respective parameters obtained from 20 healthy persons as normal control.Meantime,the degree of neuro-deficit in the two groups was evaluated by NIH Stroke scale and Barthel index on d0,d7,d14 and d21.Results SOCS-3 expression at d0,d3,d7;and TNF-α expression at d0,d7 were higher in the two patients’ groups significantly than in normal controls(P<0.05).As compared with the control group,on d7,SOCS-3 expression was higher(360.98±123.31 ng/L vs.281.87±133.66 ng/L) and TNF-α expression was lower(35.72±19.94 ng/L vs.49.86±34.79 ng/L),while the NIHSS score on d7 and d14,as well as the Barthel index on d14 and d21 were lower in the treatment group(all P<0.05).Conclusions The acting mechanism of HTG for promoting nerve function recovery of ACI patients is possibly and closely related with the up-regulation of the inflammation suppressive factor SOCS-3,the down-regulation of the inflammation promoting factor TNF-α,and the elimination of secondary inflammatory injury after cerebral ischemia. |
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