| 张洁,张莉,王军,韩春.芍根汤防治急性放射性食管炎的临床观察[J].,2010,30(12):1272-1274 |
| 芍根汤防治急性放射性食管炎的临床观察 |
| Clinical Observation on Effect of Shaogen Decoction for the Prevention and Treatment of Acute Radiation Esophagitis |
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| DOI： |
| 中文关键词: 芍根汤 急性放射性食管炎 预防 治疗 |
| 英文关键词:Shaogen Decoction acute radiation esophagitis prevention treatment |
| 基金项目:河北省教育厅高校特色学科资助项目(No.200552);河北省中医药管理局科研课题(No.2008033) |
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| 中文摘要: |
| 目的观察芍根汤对急性放射性食管炎的预防及治疗作用。方法将同期放化疗的60例胸部肿瘤患者分为中药组及对照组。中药组自放疗首日开始口服中药芍根汤(山豆根10g白芍30g玄参15g白及15g三七3g等药组成),每次10mL,每天3次,发生2级及以上的放射性食管炎后,改为每次10mL,每2h1次,含服徐咽,用药5min内禁食水,连用7天;对照组在发生2级及以上食管炎后静脉滴注抗生素(头孢呋辛钠4.5g)加激素(地塞米松5mg)治疗,连用7天,观察两组发生2级及以上急性放射性食管炎的发生率、发生时间、持续时间、放射性食管炎的治疗效果及两组应用抗生素的比例。结果两组2级及以上放射性食管炎的发生率分别为33.33%和63.33%,中药组明显低于对照组(χ2=5.406,P<0.05);两组均出现不同程度的食管急性毒性反应,中药组首次出现症状的时间平均为放疗后(19.8±7.4)天,对照组为(20.2±9.6)天,中药预防可明显延迟食管炎的发生时间(t=2.130,P<0.05);临床症状持续的平均时间分别为中药组(56.4±19.5)天,对照组(58.2±15.0)天,两组比较,差异亦有统计学意义(t=2.441,P<0.05),中药组持续时间较短。中药治疗2级及以上食管炎具有与西药同等的疗效,但中药组可明显降低应用抗生素及激素的比例。结论在放化疗同步的治疗中,芍根汤可降低2级及以上食管炎的发生率,延迟急性放射性食管炎的发生时间,缩短临床症状持续时间,减少应用抗生素及激素的比例,对放射性食管炎的治疗作用具有与西药同等的疗效。 |
| 英文摘要: |
| Objective To observe the effect of Shaogen Decoction (SGD) for the prevention and treatment of acute radiation esophagitis (ARE).Methods Sixty patients with breast tumor receiving chemo/radiotherapy were assigned to two groups,the SGD group and the control group.The patients in the SGD group were administered with SGD,a Chinese preparation consisted of Radix Sophorae tonkinensis 10g,Radix Paeoniae Alba 30g,Radix Scrophulariae 15g,Rhizoma Bletillae 15g,Radix Notoginseng 3g,etc.,starting from the initial day of radiotherapy,10mL,thrice a day,while in case of 2nd or over 2nd grade ARE occurred,it was changed to 10mL,every 2h,medicated by keeping in mouth and slowly swallowed followed with 5-min forbiddance of food and water.The patients in the control group were treated,in case of 2nd or over 2nd grade ARE occurred,with antibiotic drugs (such as cefuroxime 4.5g) and hormone (dexamethasone 5mg) by intravenous infusion for 7 days.The incidence,happening time,and retaining time of ARE,therapeutic effect on it,as well as the proportion of patients for whom antibiotics and hormone were used in the two groups were observed.Results The incidence of 2nd or over 2nd grade ARE in the SGD group and the control group was 33.33% and 63.33%,respectively,that in the former was significantly lower (χ2= 5.406,P<0.05).Different degrees of acute esophageal toxic response occured in both groups,initially presenting at 19.8±7.4 days in the SGD group and at 20.2±9.6 days in the control group after radiotherapy,that was delayed in the former (t=2.130,P<0.05).Clinical symptom of ARE retained for 56.4±19.5 days and 58.2±15.0 days in the two groups,respectively,it was shorter in the SGD groups (t= 2.441,P<0.05).Moreover,the proportion of patients for whom antibiotics and hormone were used in the SGD group was less.Conclusion SGD acted,in coordinating with chemo-radiotherapy,to reduce the incidence,retard the happening and shorten the retaining time of 2nd or over 2nd grade ARE,and reduce the proportion of patients needing antibiotics and hormone treatment as well,showing equivalent efficacy in treating ARE as Western drugs. |
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