| 赵培欣,江珊.丹红注射液对PCI术后患者ET-1、sP-sel及hs-CRP的影响[J].,2011,31(1):11-14 |
| 丹红注射液对PCI术后患者ET-1、sP-sel及hs-CRP的影响 |
| Effect of Danhong Injection on ET-1,sP-sel,and hs-CRP in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention |
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| DOI： |
| 中文关键词: 丹红注射液 急性冠脉综合征 经皮冠状动脉介入治疗 内皮素-1 可溶性P选择素 高敏C反应蛋白 |
| 英文关键词:Danhong Injection acute coronary syndrome percutaneous coronary intervention endothelin-1 soluble P-selectin high sensitivity C-reactive protein |
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| 中文摘要: |
| 目的观察急性冠状动脉综合征(acute coronary syndrome,ACS)患者经皮冠状动脉介入(percu-taneous coronary intervention,PCI)治疗前后血浆内皮素-1(endothelin-1,ET-1)、可溶性P选择(soluble P-se-lectin,sP-sel)及高酶C反应蛋白(high sensitivity C-reactive protein,hs-CRP)的水平变化,评价丹红注射液对ET-1、sP-sel及hs-CRP的影响并探讨其可能作用机制。方法将拟行PCI术的ACS患者70例随机分为丹红组(36例)与常规组(34例)常规组,给予介入治疗及常规用药;丹红组在常规治疗的基础上,从术后当日至术后第14日,用丹红注射液40mL稀释于5%的葡萄糖注射液250mL中静脉滴注,1次/日。分别于术前(T0)、术后即刻(T1)、术后第24h(T2)、术后第14日(T3)采肘静脉血5mL,分离血浆后用酶联免疫吸附双抗体夹心法(ELISA)测定血浆ET-1、sP-sel及hs-CRP的浓度进行不同时间点三者水平的组内组间比较,另选20名正常体检者做对照。结果与对照组比较,丹红组与常规组T0,T1及T2时间点血浆ET-1、sP-sel及hs-CRP的水平均较对照组有明显升高,差异有统计学意义(P<0.01);T3时间点丹红组与常规组血浆ET-1、sP-sel及hs-CRP的水平均较对照组略降低,但差异无统计学意义(P>0.05)。与常规组比较,丹红组T0,T1及T2时间点血浆ET-1、sP-sel及hs-CRP的水平差异均无统计学意义(P>0.05),T3时间点丹红组ET-1、sP-sel及hs-CRP的水平均低于常规组(P<0.05,P<0.01)。结论在常规治疗的基础上加用丹红注射液治疗2周可明显降低ACS患者血浆ET-1、sP-sel及hs-CRP水平,表明其有一定的保护内皮细胞、抑制血小板的活化及抑制炎症反应功能。 |
| 英文摘要: |
| Objective To observe the effect and explore the action mechanism of Danhong Injection (DHI) on serum levels of endothelin-1 (ET-1),soluble P-selectin (sP-sel) and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods Seventy ACS patients scheduled to receive PCI were assigned to two groups. Around PCI,the 34 patients in the control group were treated with conventional therapy and the 36 in the DHI group treated with conventional therapy combined with DHI treatment given from the day of PCI to the 14th day after operation at the dose of 40 mL per day by dissolving in 250 mL of 5% glucose for venous dripping. Plasma levels of ET-1,sP-sel and hs-CRP were detected using ELISA at various time points:before PCI (T0),after PCI (T1),24 h (T2) and 2 weeks (T3) after PCI. The outcomes were compared between the two groups,and compared with those obtained from 20 healthy persons set as the normal control. Results All the three indices in the two patients’ group at T0,T1 and T2 were higher than those in the normal control respectively (P<0.01),while at T3,the indices in the DHI group were lower than the normal control (P>0.05). Comparisons between the two patients’ group showed that the indices were not different at T0,T1 and T2,but at T3,all were lower in the DHI group than in the control group (P<0.05,P<0.01). Conclusions Combined conventional therapy with DHI for 2 weeks can significantly reduce the plasma levels of ET-1,sP-sel and hs-CRP in ACS patients after PCI,suggesting that DHI has certain effects in protecting the endothelial function,inhibiting platelet activation and suppressing inflammatory reaction. |
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