| 卓冬婷,阙铁生,吕军影,李佳荃,黄李平.加味藿朴夏苓汤对脾胃湿热证临床疗效及舌上皮细胞凋亡的影响[J].,2011,31(2):168-171 |
| 加味藿朴夏苓汤对脾胃湿热证临床疗效及舌上皮细胞凋亡的影响 |
| Effect of Modified Huopo Xialing Decoction in Treating Pi-Wei Dampness-heat Syndrome and Its Impact on the Tongue Epithelial Cell Apoptosis |
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| DOI： |
| 中文关键词: 加味藿朴夏苓汤 脾胃湿热证 细胞凋亡 |
| 英文关键词:modified Huopo Xialing Decoction Pi-Wei dampness-heat syndrome cell apoptosis |
| 基金项目:广西壮族自治区卫生厅立项课题(No.Z2008103);广西自然科学基金课题(No.桂科自0447062) |
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| 中文摘要: |
| 目的探讨加味藿朴夏苓汤对脾胃湿热证的临床疗效,并观察其对黄腻苔舌上皮细胞凋亡的影响。方法 50例脾胃湿热证患者按就诊顺序分为治疗组(30例)和对照组(20例),分别给予加味藿朴夏苓汤及多潘立酮片治疗,疗程均为2周。30名健康志愿者为正常组。观察治疗组和对照组治疗前后舌苔变化、主要证候分级评分和临床疗效;运用TUNEL技术检测正常组及脾胃湿热证患者的舌上皮细胞凋亡指数。结果治疗前脾胃湿热证患者舌上皮细胞凋亡指数低于正常组(P<0.01,P<0.05);治疗后治疗组舌上皮细胞凋亡指数较治疗前增加(P<0.01),与正常组比较差异无统计学意义(P>0.05),对照组无明显变化。治疗组治疗后舌苔分级与治疗前比较差异有统计学意义(P<0.01),对照组无明显改善(P>0.05)。治疗后治疗组与对照组证候总积分均显著降低(P<0.01),治疗前后差值比较,治疗组改善作用优于对照组(P<0.01)。治疗组临床总有效率优于对照组(90%vs65%,P<0.01)。结论加味藿朴夏苓汤对脾胃湿热证有较好的临床疗效,且可加速舌上皮细胞凋亡,对黄腻苔有显著的消退作用。 |
| 英文摘要: |
| Objective To study the effects of modified Huopo Xialing Decoction (HXD) in treating patients of Pi-Wei dampness-heat syndrome (PWDHS) and its impact on epithelial cell apoptosis of tongue. Methods Fifty patients with PWDHD were randomized depending on their visiting sequence into two groups,the 30 patients in the treatment group treated with HXD and the 20 in the control group treated with Domperidone. The therapeutic course for both groups was 2 weeks. Besides,a normal control group consisting of 30 healthy volunteers was set up. The changes of tongue fur,grade of major syndromes in different groups were observed and scored before and after treatment to evaluate the therapeutic effectiveness,and the apoptotic index (AI) was estimated using TUNEL technique. Results AI in the two patient groups before treatment was obviously lower than that in the normal group (P<0.01 or P<0.05); after treatment,AI in the treatment group increased significantly (P<0.01),with no difference from that in the normal group (P>0.05),while in the control group,it only showed a slight trend of increasing. Similar outcome of tongue fur grades was seen in the two groups,it was improved significantly (P<0.01) in the treatment group but insignificantly in the control group (P>0.05). After treatment,syndrome scoers were both lower in the two groups (P<0.01),but the decrement in the treatment group was more significant than that in the control group (P<0.01). Comparison between groups showed that the total effective rate in the treatment group was significantly superior to that in the control group (90% vs 65%,P<0.01). Conclusion HXD has good clinical efficacy in treating PWDHS,and has good effect in alleviating the greasy yellow tongue fur in patients with PWDHS by accelerating the tongue epithelial cell apoptosis. |
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