| 李杰,贾钰华,程欣.肺与大肠相表里物质基础研究方法的探讨[J].,2011,31(2):256-259 |
| 肺与大肠相表里物质基础研究方法的探讨 |
| Discussion on Method of Studying Material Base on Chinese Medical Theory of ’Fei and Dachang Being Interior-exteriorly Correlated’ |
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| DOI： |
| 中文关键词: 肺与大肠相表里 物质基础 研究方法 |
| 英文关键词:Fei and Dachang being interior-exteriorly related material base research method |
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| 中文摘要: |
| 通过回顾肺与大肠相表里研究的相关文献,认识到目前物质基础研究存在研究方法效率不高,忽视呼吸道和肠道组织中的微生态环境、中医学功能态条件及临床研究设计不符合循证医学要求等不足。提出应根据肺与大肠网络联系结构的特点,摒弃以某一种物质或某一条线性联系路径为起点的研究方法,以处在网络联系结构两个终端的呼吸系统和肠道组织及中间信息联系的关键点血清三者的变化关联作为切入点,应用微生态学、蛋白组学和代谢组学方法高通量地筛选相关物质,同时抓住网络联系中尽可能多的网结,并以此为基础,逐步完善网络协调机制的研究,建立起新的网络机制研究策略。 |
| 英文摘要: |
| By reviewing pertinent literatures,we found that there existed some defects in studying material base on Chinese medical theory of "Fei and Dachang being interior-exteriorly related" ,such as the low efficacy of research methods; the neglect of intestinal and respiratory microhabitat and Chinese medical functional condition; and the unconformity of research design with evidence-based medicinal requirements. Thereby,the authors offered that the researches method of initiating merely from sole material or line linkage path should be rejected. The new research strategy should be established based on the feature of the lung and large intestine network connective structure,cutting-in from correlative changes in the two terminals (respiratory system and intestinal tissue),and the intermedial key knot of connection (blood serum),screen out in high throughput the relevant materials adopting microecologic,proteomic and metabonomic techniques,and catch hold of the knots of network as much as possible. Based on these to perfect the researches on coordinating mechanism of the network,and to establish a new strategy for future researching. |
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