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王晓南,吴青,杨旭,张连生,吴一品,卢聪.雷公藤红素对白血病细胞Akt信号通路的影响及在细胞凋亡中的作用[J].,2011,31(2):228-232

雷公藤红素对白血病细胞Akt信号通路的影响及在细胞凋亡中的作用

Effect of Celastrol on Akt Signaling Pathway and Apoptosis of Leukemic K562 Cell Line

DOI：

中文关键词: 雷公藤红素 K562细胞 Akt Caspase-3 Caspase-8

英文关键词:celastrol K562 cell Akt Caspase-3 Caspase-8

基金项目:湖北省教育厅基金资助项目(No.B20101107)

王晓南吴青杨旭张连生吴一品卢聪

1.武汉科技大学医学院(武汉430000)
；2.华中科技大学附属协和医院血液病研究所(武汉430022)

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中文摘要:

目的研究雷公藤红素（celastrol)对人类白?∠赴闗562细胞Akt信号通路的影响及其作用。

英文摘要:

Objective To research the effect and route of celastrol on Akt signaling pathway of human leukemia cell line K562 apoptosis. Methods The activities of K562 proliferation cells were detected by MTT assay; cell apoptosis was detected by Hoechst 33258 staining assay,DNA fragmentation assay,and Annexin V/PI double-labeled cytometry; the expression and phosphorylation level of Caspase family members and AKT signaling pathway related proteins were determined by Western blot before and after celastrol treatment,an...

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