| 沙吉旦·阿不都热衣木,热娜古丽·艾则孜,麦热也木古·米吉提,金伟,哈木拉提·吾甫尔.恶性肿瘤维医证型与血栓前状态分子标志物的关系研究[J].,2011,31(3):346-349 |
| 恶性肿瘤维医证型与血栓前状态分子标志物的关系研究 |
| Study on the Correlation between Prethrombotic Biomarkers and Traditional Uyghur Medicinal Syndromes of Malignant Tumor |
| |
| DOI： |
| 中文关键词: 恶性肿瘤 维医证型 血栓前状态 |
| 英文关键词:malignant tumor traditional Uyghur medicine syndrome prethrombotic state |
| 基金项目:国家杰出青年基金项目(No.30525023) |
|
| Hits: 1432 |
| Download times: 0 |
| 中文摘要: |
| 目的探讨恶性肿瘤患者维医证型与血栓前状态分子标志物的关系。方法 随机选取住院治疗的恶性肿瘤患者159例,按照维医理论进行分型,并采用流式细胞术、放射免疫法和ELISA方法等检测各证型患者外周血中血小板膜糖蛋白(CD41、CD62p)的表达及内皮素(ET-1)、组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制剂(PAI)、血浆纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)及活化部分凝血活酶时间(APTT)水平。结果 恶性肿瘤患者异常黑胆质型68例,异常血液质型34例,异常黏液质型31例,异常胆液质型26例。与正常对照组比较,异常黑胆质型肿瘤组和非异常黑胆质(包括异常血液质、异常黏液质、异常胆液质型)型肿瘤组CD62p、PAI、ET-1水平升高(P<0.05),FIB、t-PA水平降低(P<0.05),PT延长(P<0.05),APTT缩短(P<0.05),CD41、TT在各组间比较差异无统计学意义(P>0.05);异常黑胆质型肿瘤组与异常血液质型肿瘤组及异常胆液质型肿瘤组比较,ET-1水平升高(P<0.05);与异常黏液质型肿瘤组比较,CD62P阳性百分数增多(P<0.05);而CD41阳性百分数、t-PA及PAI-1含量、PT、TT和APTT在各型肿瘤组之间比较差异无统计学意义(P>0.05)。结论 各异常体液型恶性肿瘤患者均存在不同程度的血栓前状态改变,表现在血管内皮细胞损伤、血小板活化、血液黏度增高、纤溶功能降低,且以异常黑胆质型恶性肿瘤患者变化较为明显。 |
| 英文摘要: |
| Objective To study the correlation between prethrombotic biomarkers and traditional Uyghur medicinal syndromes of malignant tumor.Methods One hundred and fifty-nine malignant tumor inpatients were randomly selected and typed according to traditional Urgur medicine theories.The expressions of peripheral platelet membrane glucoprotein(CD41 and CD62p),levels of serum endothelin(ET-1),plasma tissue plasminogen activator(t-PA),plasminogen activator inhibitor(PAI),plasma fibrinogen(FIB),prothrombin time(PT),and thrombin time(TT),and activated partial thromboplastin time(APTT) were detected by flow cytometry,radioimmunoassay,and enzyme-linked immunosorbnent assay(ELISA) respectively.Results The patients were typed as 68 of abnormal Savda syndrome,34 of abnormal Khan syndrome,31 of the abnormal Sepra syndrome,and 26 of the abnormal Belghem syndrome.Compared with the control group,the levels of CD62p,PAI,and ET-1 increased,levels of FIB and t-PA decreased,PT prolongated and APTT shortened in the abnormal Savda group and the non-abnormal Savda group(including abnormal Khan,abnormal Sepra,and abnormal Belghem types)(all P<0.05).No significant difference of CD41or TT was shown in inter-group comparison(P>0.05).Compared with abnormal Khan and Belghem groups,the ET-1 level increased in the abnormal Savda group(P<0.05).Compared with the abnormal Sepra group,the CD62p positive percentage increased in abnormal Savda group(P<0.05).No significant difference in CD41 positive percentage,t-PA or PAI-1 contents,PT,TT,or APTT was shown in patients of different traditional Uyghur medicine syndrome groups(P>0.05).Conclusions Prethrombotic changes existed in malignant tumor patients of different Uyghur abnormal syndrome types,manifested as injuries of vessel epithelial cells,platelet activation,increased blood viscosity,lowered fibronolytic function.The prethrombotic changes were more obviously seen in the abnormal Savda group. |
| View Full Text View/Add Comment Download reader |
|
|
|
