| 邹和群,邹贵勉,晏强,谢申平,眭维国,马井生,梁桂荣,郭骏军,陈怀周,车文体.五酯胶囊在肾移植术后的临床应用研究[J].,2011,31(9):1213-1215 |
| 五酯胶囊在肾移植术后的临床应用研究 |
| Study on the Clinical Application of Wuzhi Capsule after Renal Transplantation |
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| DOI： |
| 中文关键词: 五酯胶囊 他克莫司 血药浓度 肾移植 |
| 英文关键词:Wuzhi Capsule tacrolimus blood concentration renal transplantation |
| 基金项目: |
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| 中文摘要: |
| 目的探讨在肾移植术后受者应用五酯胶囊(五味子甲素)提高免疫抑制剂他克莫司(tacrolimus,Tac)血药浓度同时对肝脏具有保护作用。方法将73例肾移植术后受者随机分为2组,五酯胶囊组35例,对照组38例。两组抗排异治疗方案均为Tac+霉酚酸酯胶囊(MMF)+泼尼松,五酯胶囊组加服五酯胶囊,两组均服药12个月为1个疗程,并分别于服药1周,1、3、6、12个月时采用微粒子酶免疫法(MEIA法)检测Tac血浓度值变化;同时检测肝、肾功能,血糖等。结果五酯胶囊组服药1周,Tac血浓度平均升高67.2%,治疗1～12个月间Tac用量五酯胶囊组均显著低于对照组(P<0.01);而肝、肾功能及血糖与对照组比较,差异无统计学意义(P>0.05)。结论五酯胶囊可显著提高肾移植后Tac血药浓度,并明显减少受者Tac用量,无明显的不良反应。 |
| 英文摘要: |
| Objective To study the protection of Gan by using deoxyschizandrin(Wuzhi Capsule,WC) in the renal transplantation recipients while increasing the blood concentration of tacrolimus(Tac).MethodsSeventy-three renal transplant recipients were randomly assigned to two groups,i.e.,35 in the WC group and 38 in the control group.All patients received Tac+MMF+Pred triple immunosuppressive therapy.WC was additionally given to patients in the WC group.One year was taken as one therapeutic course.Changes of the blood concentration of Tac were detected one week,1,3,6,and 12 months after medication in the two groups using microparticle enzyme immune assay(MEIA).Meanwhile,the liver and kidney functions,and the blood glucose were tested.Results One week after the application of WC,the blood Tac concentration increased 67.2% averagely.During the 1-12 months of WC treatment,the Tac dosage was significantly lower in the WC group than in the control group(P<0.01).There was no significant difference in the liver and renal functions,or the blood glucose levels between the two groups(P>0.05).Conclusion WC could significantly increase the blood Tac concentration of renal transplant recipients,reduce their Tac dosages,with no obvious adverse reaction. |
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