| 陶黎明,熊建萍,刘同欣,龙贺明,孙哲,张凌,项小军,余锋.小剂量番泻叶浸液预防治疗化疗后便秘自身交叉对照研究[J].,2012,32(1):47-49 |
| 小剂量番泻叶浸液预防治疗化疗后便秘自身交叉对照研究 |
| A Crossover Control Study of Prophylactic Treatment of Chemotherapy-induced Constipation by Senna Extract |
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| DOI： |
| 中文关键词: 番泻叶 便秘 化疗 恶性肿瘤 |
| 英文关键词:senna constipation chemotherapy malignant tumor |
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| 中文摘要: |
| 目的观察40mg/kg番泻叶浸液预防治疗化疗后便秘的疗效。方法 82例化疗后曾出现过便秘的患者分为AB与BA组,采用自身交叉对照。AB组指第1个化疗周期为服用番泻叶浸液,第2个化疗周期为进粗纤维饮食组;BA组则相反。观察番泻叶浸液及粗纤维饮食对化疗后缓解便秘的有效率;并比较两者对化疗后消化道反应及血液毒性反应的差别;了解服用番泻叶浸液后患者的腹痛及大便性状情况。结果番泻叶浸液对便秘总有效率为92.68%,粗纤维饮食为10.93%,两者比较差异有统计学意义(P<0.01)。两者化疗后Ⅱ度以上的中性粒细胞下降、血红蛋白下降、血小板下降、恶心、呕吐等不良反应率比较差异无统计学意义(P>0.05);服用番泻叶浸液后Ⅱ度以上腹痛出现率8.54%;大便性状分布中,软便率占35.53%。结论 40mg/kg番泻叶浸液预防治疗恶性肿瘤化疗后便秘,剂量适宜,使用方便、安全,具有较好疗效。 |
| 英文摘要: |
| Objective To observe the prophylactic effects of senna extract 40 mg/kg on chemotherapy-induced constipation.Methods Eighty-two patients suffering from constipation after chemotherapy were assigned to Group AB and Group BA.Group AB referred to patients who first took senna extract in the 1st chemotherapeutic course and the crude fiber diet in the 2nd chemotherapeutic course.But the sequence was just the opposite in Group BA.The effective rates of relieving chemotherapy-induced constipation by senna extract and by the crude fiber diet were observed.The differences of the digestive tract reaction and the hematotoxicity reaction were compared.The conditions of patients’ abdominal pain and stool properties were observed after they took senna extract.Results The effective rate of constipation by taking senna extract was 92.68% and that by the crude fiber diet was 10.93%,with statistical difference shown(P<0.01).There was no statistic difference in adverse reaction rate such as decreased neutrophils over degree Ⅱ,decreased hemoglobin,decreased platelet,nausea,vomit,etc.(P>0.05).The occurrence rate of abdominal pain over degree Ⅱ after taking senna was 8.54%.In the distribution of stool properties,the rate of loose stool was 35.53%.Conclusion Senna extract 40 mg/kg was effective and safe in treating chemotherapy-induced constipation. |
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