| 周滔,张声生,崔超,吴兵,汪红兵,陶琳,陈明,唐博祥,翟兴红,张琳,朱培一,沈洪.中医药分期二步法治疗溃疡性结肠炎的临床研究[J].,2012,32(2):172-175 |
| 中医药分期二步法治疗溃疡性结肠炎的临床研究 |
| Clinical Study of Comprehensive Treatment of Chinese Medicine in treating Ulcerative Colitis Based on Two Steps according to the Stage of Disease |
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| DOI： |
| 中文关键词: 中医药 溃疡性结肠炎 生活质量 随机对照试验 临床疗效 |
| 英文关键词:Chinese medicine ulcerative colitis quality of life randomized controlled trail clinical efficacy |
| 基金项目:国家“十一五”科技支撑计划分课题(No.2006BAI04A14) |
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| 中文摘要: |
| 目的观察中医药分期二步法干预方案治疗溃疡性结肠炎的临床疗效和优势。方法 53例轻、中度初发或复发型溃疡性结肠炎活动期湿热内蕴证患者随机分为中药组27例及西药组26例。中药组活动期予清肠化湿方口服联合灌肠方外治;缓解期扶正清肠方口服,若病情复发加用灌肠方,同时根据症状特点进行对症加减。西药组活动期给予美沙拉嗪肠溶片1.0g,每日4次口服治疗;缓解期给予美沙拉嗪肠溶片0.5g,每日3次口服治疗,若病情复发恢复为活动期治疗方案。分别于治疗后28、56、84天观察患者主要临床症状、中医证候、诱导缓解率和生活质量变化。结果治疗84天后,中药组腹泻、脓血便、腹痛均较治疗前明显好转(P<0.05),且对腹泻、脓血便的缓解优于西药组(P<0.05)。中药组治疗28、56、84天后,中医证候疗效分别为77.78%、77.78%、88.89%,诱导缓解率分别为63.0%、77.8%、88.9%,均优于同期西药组(P<0.05)。治疗84天后,两组患者生活质量各维度胃肠症状、全身症状、情感能力、社会能力等方面较治疗前均显著改善(P<0.05),且中药组患者生活质量各维度改善程度均优于西药组(P<0.05)。结论中医药分期二步法干预方案能有效改善溃疡性结肠炎患者的主要临床症状,改善患者中医证候,提高溃疡性结肠炎缓解率和患者整体生活质量,具有良好的临床疗效。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of comprehensive treatment of Chinese medicine in treating ulcerative colitis(UC) according to syndrome differentiation therapy and the stage of disease.Methods Fifty-three patients with mild or moderate,initial onset or relapsed active UC of large intestinal dampness-heat syndrome were randomly assigned to two groups,the treatment group(27 cases) and the control group(26 cases).The treatment group was treated with oral Qingchang Huashi Recipe(QHR) and external application of Guanchang Recipe(GR) in the active stage,oral administration of Fuzheng Qingchang Recipe in the remission stage.Symptomatic modification was performed according to the features of the symptoms.Patients in the control group were treated with oral Mesalazine enteric coated tablet(MSRT,1.0 g,4 times daily) in the active stage,oral administration of MSRT(0.5 g,three times daily) in the remission stage.The main clinical symptoms,Chinese medicine syndrome,induced remission rate,and changes of quality of life were observed on the 28th,56th,and 84th day after treatment.Results After 84 days of treatment,the scores of the symptoms such as diarrhea,passing stool with pus and blood,and the abdominal pain in the treatment group were obviously improved when compared with before treatment(P<0.05).The scores of the symptoms such as diarrhea,and passing stool with pus and blood in the treatment group were better than those in the control group(P<0.05).After 28,56,and 84 days of treatment,the clinical efficacy of Chinese syndromes were 77.78%,77.78%,and 88.89%,respectively,and the induced remission rates were 63.0%,77.8%,and 88.9%,respectively in the treatment group,better than those in the control group of the same phase(P<0.05).After 84 days of treatment,the scores of the quality of life,the general symptoms,the emotional capacity,and the social capacity,etc.in the treatment group and the control group were improved than before treatment(P<0.05).Besides,the scores of the quality of life in the treatment group were superior to that in the control group(P<0.05).Conclusions Comprehensive treatment of Chinese medicine in treating ulcerative colitis based on two steps according to the stage of disease can effectively improve the main symptoms of UC patients,improve the Chinese syndromes,elevate the clinical remission rate and patients′ quality of life.It showed favorable clinical efficacy. |
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