| 王繁盛,吴启富,戚晶敏,接红宇.强骨关节冲剂联合双醋瑞因治疗膝骨关节炎临床研究[J].,2012,32(6):779-781,792 |
| 强骨关节冲剂联合双醋瑞因治疗膝骨关节炎临床研究 |
| Clinical Study of Qianggu Granule and Diacerein Capsule in Treating Knee Osteoarthritis |
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| DOI： |
| 中文关键词: 膝骨关节炎 强骨关节冲剂 双醋瑞因 联合用药 |
| 英文关键词:knee osteoarthritis Qianggu Granule Diacerein Capsule medication in combination |
| 基金项目: |
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| 中文摘要: |
| 目的观察强骨关节冲剂联合双醋瑞因治疗肝肾不足、筋脉瘀滞型膝骨关节炎(knee osteroarthritis,KOA)的临床疗效,探讨中西药联合治疗KOA的临床优势。方法将符合标准的90例患者随机分为中药组(30例,强骨关节冲剂治疗)、西药组(30例,双醋瑞因治疗)、联合组(30例,强骨关节冲剂联合双醋瑞因治疗)。治疗3个月前后对各组患者的症状、体征进行评分,同时对C反应蛋白(CRP)、ESR、TNF-α、综合疗效、不良反应等方面进行评估。结果 3组均可明显缓解疼痛,改善关节功能,提高日常生活能力,各组治疗前后症状、体征积分及CRP、ESR、TNF-α检测指标水平比较,差异均有统计学意义,且联合组优于另两组(P<0.05);3组综合疗效比较,联合组疗效明显优于另两组,差异有统计学意义(P<0.01)。结论应用强骨关节冲剂联合双醋瑞因治疗肝肾不足、筋脉瘀滞型KOA,其综合疗效明显优于单用强骨关节冲剂或双醋瑞因治疗,且未见明显的不良反应。 |
| 英文摘要: |
| Objective To observe the therapeutic efficacy of Qianggu Granule(QGG),Diacerein Capsule(DC),and QGG+DC in treating knee osteoarthritis(KOA,belonging to Gan-Shen insufficiency induced vein stasis syndrome),and to explore the clinical advantages of QGG+DC.Methods Ninety patients in line with the diagnosis standard were randomly assigned to three groups,i.e.,the QGG group(30 case,treated by QGG),the Western medicine treatment group(30 case,treated by DC),and the combination therapy group(30 case,treated by QGG+DC).Then the patients’ symptoms and signs were scored.Meanwhile,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),tumor necrosis factor α(TNF-α),comprehensive efficacy,and adverse reactions,etc.were assessed.Results The ache could be obviously alleviated,the patients’ joint function could be improved,and their quality of daily activities could be elevated in all the 3 groups.There was statistical difference in the symptoms and signs scores,CRP,ESR,and TNF-α before and after treatment(P<0.05).Better effects were obtained in the combination therapy group(P<0.05).As for the comprehensive efficacy,it was better in the QGG+DC group than in the QGG group and the DC group,showing statistical difference(P<0.01).Conclusions The comprehensive therapeutic efficacy of applying QGG+DC in treating KOA(belonging to Gan-Shen insufficiency induced vein stasis syndrome) was superior to using QGG or DC alone.Besides,no obvious adverse reaction occurred. |
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