| 肖琳,李岩.加减半夏厚朴汤治疗伴心理因素功能性消化不良随机对照研究[J].,2013,33(3):298-302 |
| 加减半夏厚朴汤治疗伴心理因素功能性消化不良随机对照研究 |
| Randomized Controlled Trial of Modified Banxia Houpo Decoction in Treating Functional Dyspepsia Patients with Psychological Factors |
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| DOI： |
| 中文关键词: 加减半夏厚朴汤 功能性消化不良 焦虑 抑郁 |
| 英文关键词:Modified Banxia Houpo Decoction functional dyspepsia anxiety depression |
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| 中文摘要: |
| 目的 观察加减半夏厚朴汤治疗伴心理因素的功能性消化不良（functional dyspepsia，FD）患者的临床疗效，并与多潘立酮、路优泰及二者联合应用进行比较。方法 选择存在焦虑和（或）抑郁的FD患者89例，随机分为加减半夏厚朴汤组（23例）、多潘立酮组（22例）、路优泰组（22例）和多潘立酮加路优泰组（22例），每组分别给予相应药物治疗4周。治疗前后分别以汉米尔顿抑郁量表（Hamilton Depression Scale，HAMD）和汉米尔顿焦虑量表（Hamilton Anxiety Scale，HAMA）进行心理评分；通过FD症状评分，计算FD症状改善率、FD症状评分<2分及FD症状改善率>50%患者所占比例；通过胃排空检查，比较各组患者胃排空率。结果 各组患者治疗前HAMD评分、HAMA评分、FD症状评分及胃排空率比较，差异均无统计学意义（P>0.05）。治疗4周后，加减半夏厚朴汤组、路优泰组和多潘立酮加路优泰组心理评分和FD症状评分均显著下降（P<0.01， P<0.05）；加减半夏厚朴汤组心理评分和FD症状评分均明显低于多潘立酮组（P<0.05）。多潘立酮加路优泰组FD症状改善率以及FD症状评分<2分和FD症状改善率>50%患者所占比例最高，加减半夏厚朴汤组次之，多潘立酮组最低。各组治疗后胃排空率均较本组治疗前明显增加（P<0.01）；各组间比较，差异无统计学意义（P>0.05）。结论 加减半夏厚朴汤对伴心理因素的FD具有一定疗效，与其改善心理状态和促进胃排空有关；且加减半夏厚朴汤对心理状态和症状的改善优于多潘立酮。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of Modified Banxia Houpo Decoction （MBHD） in treating patients with functional dyspepsia （FD） accompanied with psychological factors， and to compare it with Domperidone， Neurostan， and Domperidone+Neurostan. Methods Recruited were 89 FD patients accompanied with anxiety and/or depression， who were randomly assigned to four groups， i.e.， the MBHD group （23 cases）， the Domperidone group （22 cases）， the Neurostan group （22 cases）， and the Domperidone+Neurostan group （22 cases）. Corresponding medication lasted for 4 weeks. The psychological scoring was performed using Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA）. The improvement rate of FD symptoms， the ratios of FD symptoms scoring<2， and the improvement rate of FD symptoms>50% were calculated by the scoring of FD symptoms. The gastric emptying rates of patients in each group were compared using the examinations of gastric emptying. Results There was no statistical difference in pre treatment HAMD， HAMA， FD symptoms scoring， and the gastric emptying rate among the 4 groups （P>0.05）. The psychological scoring and FD symptoms scoring significantly decreased in the 4 groups except the Domperidone group after 4 week treatment （P<0.01， P<0.05）. The psychological scoring and FD symptoms scoring were obviously lower in the MBHD group than in the Domperidone group （P<0.05）. The improvement rate of FD symptoms， the ratios of FD symptoms scoring<2， and the improvement rate of FD symptoms>50% were the highest in the Domperidone+Neurostan group， followed by the MBHD group， and then the Domperidone group. After treatment the gastric emptying rate obviously increased in each treatment group when compared with before treatment in the same group （P<0.01）， and there was no statistical difference among these groups after treatment. Conclusions MBHD had certain therapeutic effects on FD patients accompanied with psychological factors. Its effect was associated with gastric emptying. Besides， its improvement of the psychological state and symptoms was superior to that of Domperidone. |
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