| 刘玥,史大卓,陈可冀,张京春.波动性高血压与血小板活化及其中西医结合干预策略[J].,2013,33(07):0869-0872 |
| 波动性高血压与血小板活化及其中西医结合干预策略 |
| Fluctuant Hypertension and Platelet Activation： Current Situations and Control Strategies with Integrative Medicine |
| |
| DOI：10.7661/CJIM.2013.07.0869 |
| 中文关键词: 高血压 血压波动性 血小板活化 血瘀证 活血化瘀 |
| 英文关键词:hypertension blood pressure variability platelet activation blood stasis syndrome activating blood circulation and removing stasis |
| 基金项目:国家中医临床研究基地业务建设科研专项课题（No.JDZX2012108） |
|
| Hits: 2108 |
| Download times: 1807 |
| 中文摘要: |
| 近年来大量临床研究证实，波动性高血压相对于稳定性高血压（平均动脉压增高）更能加重高血压病患者靶器官损害，增加急性心脑血管事件的发生率。对于波动性高血压及其靶器官损害的防治，已成为全球高血压病研究领域的热点和难点问题之一。高血压病患者较常见血栓栓塞性靶器官损害，血小板活化在其中起到了关键作用，但具体机制尚不明确。笔者通过对近三年来有关波动性高血压的研究进展以及其与血小板活化、中医血瘀证的关系进行深入探讨的基础上，提出波动性高血压状态下，机体已经出现了血栓前状态（prethrombotic state），即以血小板活化为突出特征、易致血栓形成、伴随血管内皮功能障碍的病理状态，血瘀证可能在波动性高血压的中医辨证分型中占有重要地位，活血化瘀方药可能具有广泛的研究应用前景。 |
| 英文摘要: |
| In recent years a huge amount of clinical studies have proved that fluctuant hypertension could aggravate the damage of target organs and increase the incidence of acute cardio /cerebrovascular events， when compared with stable hypertension ［increased mean artery blood pressure （MBP）］． How to prevent and treat fluctuant hypertension and its damage of target organs has become one of the hot and difficult problems in the field of hypertension studies all over the world. Hypertensive patients often suffer from thromboembolic target organ damage. Platelet activation plays a key role in this progress， but its concrete mechanisms have not been clearly clarified. Based on the in depth discussions on progress of fluctuant hypertension， its relationship with platelet activation and blood stasis syndrome of Chinese medicine （CM） in recent three years， we proposed， under the fluctuant hypertensive state， the prethrombotic state has occurred in the organisms， i.e.， a pathological state featured by platelet activation， liable to have vulnerable thrombopoiesis， and accompanied by endothelial dysfunction. Blood stasis syndrome might occupy an important position in CM syndrome typing of fluctuant hypertension. Herbs for activating blood circulation and removing stasis might have an extensive application prospect. |
| View Full Text View/Add Comment Download reader |
