| 冯妍,刘凯,周雪忠,陈可冀,徐浩.基于POMDP的不稳定心绞痛中西医结合治疗方案优化研究[J].,2013,33(07):0878-0882 |
| 基于POMDP的不稳定心绞痛中西医结合治疗方案优化研究 |
| Optimized Treatment Program for Unstable Angina by Integrative Medicine Based on Partially Observable Markov Decision Process |
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| DOI：10.7661/CJIM.2013.07.0878 |
| 中文关键词: 部分可观察马尔科夫决策过程 不稳定心绞痛 治疗方案优化 |
| 英文关键词:partially observable Markov decision process unstable angina optimized treatment program |
| 基金项目:北京市科技计划重大项目（No. D08050703020801） |
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| 中文摘要: |
| 目的初步优化中西医结合防治不稳定心绞痛（unstable angina， UA）的综合治疗方案。方法基于部分可观察的马尔科夫决策过程模型（Partially Observable Markov Decision Process，POMDP）的方法，选择气虚、血瘀、痰浊3个主要证侯要素，对UA住院患者的诊治情况进行深层次数据挖掘、分析，客观评价UA中西医结合的疗效。结果UA气虚证、血瘀证、痰浊证患者的推荐治疗方案依次为：硝酸酯类+他汀类+氯吡格雷+血管紧张素Ⅱ受体阻滞剂+肝素类+黄芪+党参+茯苓+白术（ADR=0.85077869）；硝酸酯类+阿司匹林+氯吡格雷+他汀类+肝素类+当归+红花+桃仁+赤芍（ADR=0.70773000）；硝酸酯类+阿司匹林+他汀类+血管紧张素转换酶抑制剂+栝蒌+薤白+半夏+陈皮（ADR=0.72509600）。结论本研究基于POMDP优化了UA的治疗方案，可作为进一步规范和制定中西医结合治疗UA方案的参考。 |
| 英文摘要: |
| ObjectiveTo initially optimize comprehensive treatment program for treating and preventing unstable angina （UA） by integrative medicine （IM）. MethodsBased on partially observable Markov decision process model （POMDP）， we chose 3 syndrome elements， i.e.， qi deficiency， blood stasis， and phlegm turbidity from UA inpatients. The efficacy of treating UA by IM was objectively assessed by in depth data mining and analyses. ResultsThe treatment programs for UA patients of qi deficiency syndrome， blood stasis syndrome， and phlegm turbidity syndrome were recommended as follows： nitrates+statins+clopidogrel+angiotensin Ⅱ receptor blockers+heparins+Astragalus membranaceus+Condonopsis+poria and large head atractylodes rhizome （ADR=0.85077869）； nitrates+aspirin+clopidogrel+statins+heparins+ Astragalus membranaceus+safflower+peach seed+red peony root （ADR=0.70773000）； nitrates+aspirin+statins+angiotensin converting inhibitors+snakegourd fruit+onion bulb+ ternate pinellia+tangerine peel （ADR=0.72509600）. Conclusion As a POMDP based optimized treatment programs for UA， it can be used as a reference for further standardization and formulation of UA program by integrative medicine. |
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