| 谭勇,李健,吕诚,吕爱平.有毒中药对证控毒科学内涵的现代诠释[J].,2013,33(10):1412-1415 |
| 有毒中药对证控毒科学内涵的现代诠释 |
| Modern Elucidative Strategies for Scientific Connotation of Controlling Toxic Reactions while Toxic Herbs Are Used to the Indication Syndrome |
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| DOI：10.7661/CJIM.2013.10.1412 |
| 中文关键词: 有毒中药 对证控毒 科学内涵 |
| 英文关键词:toxic Chinese herbs controlling toxic reaction while toxic herbs are used to the indication syndrome scientific connotation |
| 基金项目:国家自然科学基金资助项目 （No. 81273884）；中央级公益性科研院所基本科研业务费资助项目（No. ZZ070823） |
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| 中文摘要: |
| 对证使用有毒中药是控制其毒性的有效措施，用现代语言诠释其科学内涵对于健全和国际化推介中药毒性理论具有重要意义。采取能够反映中医学整体观的司外揣内研究思路和方法，从量－效/毒关系研究入手，建立恰当的对应证候动物模型，采用代谢组学、网络生物学与生物信息学理论和技术，构建并解析各层次分子网络，有望诠释有毒中药对证控毒的科学内涵。 |
| 英文摘要: |
| One of effective measures for controlling toxic reactions is to use toxic herbs according to corresponding indication syndrome. It is important to develop toxicity theory of Chinese medicine in a sound and international way using modern language to elucidate its scientific connotation. We expect to explain scientific connotation of controlling toxic reaction while toxic herbs are used to the indication syndrome by using holistic research ideas and methods capable of reflecting governing exterior to infer interior， establish appropriate corresponding syndrome animal models by cutting into dose effect/toxicity of toxic Chinese herbs， construct and analyze multi layer molecular network using theories and technologies of metabonomics， network biology， and bioinformatics. |
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