| 李晓雅,,刘龙涛.从疮疡阴毒理论探讨动脉粥样硬化斑块侵蚀[J].,2023,43(6):729-735 |
| 从疮疡阴毒理论探讨动脉粥样硬化斑块侵蚀 |
| Discussion of Atherosclerotic Plaque Erosion Based on the Theory of Yin Toxin in Sore and Ulcer |
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| DOI：10.7661/j.cjim.20230403. 040 |
| 中文关键词: 动脉粥样硬化 斑块侵蚀 疮疡 阴毒 理论探讨 中西医结合 |
| 英文关键词:atherosclerosis plaque erosion sore and ulcer yin toxin theoretical discussion integrative medicine |
| 基金项目:国家自然科学基金资助项目（No. 81973689）；北京市自然科学基金资助项目（No. 7202176）；首都卫生发展科研专项（No. 2022-2-4172）；国家中医药管理局青年岐黄学者支持项目（No.国中医药人教发[2020] 7号） |
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| 中文摘要: |
| 在急性冠脉综合征的病理发生机制中，“斑块侵蚀”与易损斑块引发的斑块破裂有本质区别，具有完整纤维帽的“斑块侵蚀”导致了约1/3的急性冠脉综合征和高达2/3的非ST段抬高型心肌梗死。精准分辨斑块侵蚀，辨证运用中西医结合诊疗可使斑块侵蚀患者有更大获益。动脉粥样硬化源于内皮受损，可从疮疡论之，疮疡之毒有阴阳之分，阴毒发于肝肾郁火，郁极发越，扰动气血，可能是斑块侵蚀的一类病机，治宜散轻而补重。 |
| 英文摘要: |
| In the pathological mechanism of acute coronary syndrome， plaque erosion is fundamentally different from plaque rupture caused by vulnerable plaque. Plaque erosion with a complete fibrous cap causes approximately 1/3 of acute coronary syndromes and up to 2/3 of non-ST-segment elevation myocardial infarctions. Accurately distinguishing plaque erosion and using an integrated approach combining Chinese and Western medicine for diagnosis and treatment can be beneficial for patients with plaque erosion. Atherosclerosis originates from endothelial damage， which can be associated with sore and ulcer. The toxin of sores is divided into yin and yang. Yin toxin occurs in the case of Gan and Shen stagnation and fire. When the inhibition becomes extreme， it can disrupt qi and blood flow， which may be one of the pathological mechanisms of plaque erosion. In treating such diseases， tonics should be emphasized over evacuation drugs. |
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