| 贾皇超,郭会军,王东利,许前磊,李鹏宇,李亚锋,杨春玲,马彦民,金艳涛.河南省艾滋病患者转服二线抗病毒治疗方案后血脂异常的发生率及影响因素分析[J].,2023,43(7):817-821 |
| 河南省艾滋病患者转服二线抗病毒治疗方案后血脂异常的发生率及影响因素分析 |
| Incidence Factors of Dyslipidemia After Switching to Second-line Antiretroviral Therapy in AIDS Patients in Henan Province |
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| DOI：10. 7661/j. cjim. 20230117.066 |
| 中文关键词: 艾滋病 二线抗病毒药物 血脂异常 患病率 影响因素 中医 |
| 英文关键词:acquired immune deficiency syndrome second-line antiviral drugs dyslipidemia prevalence influencing factors Chinese medicine |
| 基金项目:国家自然科学基金资助项目（No.81803953，No.81873289，No.81873187）;中原领军人才项目（No.ZYYCYU202012119）;河南省科技攻关项目（No.172102310325）;河南省中医药科学研究专项课题（No.20-21ZY1047，No.2022ZY1032） |
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| 中文摘要: |
| 目的 探讨河南省艾滋病（AIDS）“中医中药治疗艾滋病试点项目”地区二线抗病毒治疗方案AIDS患者血脂异常患病率及影响因素。方法 以河南省南阳市、周口市、驻马店市等AIDS “中医中药治疗艾滋病试点项目”地区2009年6月15日—2015年6月15日转服二线抗逆转录酶（ART）方案且血脂正常的HIV/AIDS患者为研究对象并对其随访1年，收集研究对象入组时信息及1年后实验室检查结果等信息。使用SPSS 22.0软件进行数据清洗整理，应用Logistic回归进行数据分析。结果 本研究纳入的2 086例调查对象，服用二线ART方案1年后患血脂异常者 504例，患病率为24.2%。多因素Logistic回归分析结果显示，女性（OR1.342， 95%CI： 1.096~1.643）、CD4+T 细胞计数>500个/mm3 （OR1.495， 95%CI： 1.160~1.927）是二线抗病毒治疗AIDS患者血脂异常危险因素 （P<0.01） 。结论河南某地区二线抗病毒治疗1年后HIV/AIDS患者血脂异常患病率约 24.2%，女性和CD4+ T 细胞计数> 500个/mm3与二线抗病毒治疗患者血脂异常有关。 |
| 英文摘要: |
| Objective To investigate the prevalence and influencing factors of dyslipidemia in acquired immune deficiency syndrome（AIDS）patients with second-line antiviral therapy in "Traditional Chinese Medicine Treatment AIDS Pilot Project" areas in Henan Province.Methods HIV/AIDS patients with normal lipids who switched to second-line antiretroviral transcriptase （ART） regimens from June 15，2009 to June 15，2015 in Nanyang City，Zhoukou City，Zhumadian City and other areas of AIDS "Traditional Chinese Medicine Treatment AIDS Pilot Project" were recruited and followed up for 1 year，Baseline data at enrollment and laboratory results 1 year later were collected.SPSS 22.0 software was used for data cleaning and sorting，Logistic regression were used for data analysis.Results In this study，of the 2 086 AIDS patients 504 patients developed dyslipidemia after 1 year of taking the second-line ART regimen，with a prevalence rate of 24.2%.Multivariate Logistic regression analysis showed that female（OR1.342，95%CI： 1.096~1.643） and CD4+ T cell count > 500/mm3 （OR1.495，95%CI： 1.160~1.927）were risk factors of dyslipidemia in AIDS patients treated with second-line antiviral therapy（P<0.01）.Conclusions The prevalence of dyslipidemia in HIV/AIDS patients was 24.2% after 1 year of second-line antiviral treatment in a region of Henan Province.Dyslipidemia was related to female and the number of CD4+ T cells > 500/mm3 after second-line antiviral treatment. |
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