| 高从容,张家庆,黄庆玲.黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究[J].,1997,(3):162-164 |
| 黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究 |
| Experimental Study on Berberin Raised Insulin Sensitivity in Insulin Resistance Rat Models |
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| DOI： |
| 中文关键词: 黄连素 二甲双胍 胰岛素敏感性 胰岛素抵抗 |
| 英文关键词:berberin metformin insulin sensitivity insulin resistance. |
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| 中文摘要: |
| 目的：观察黄连素对高脂饮食大鼠胰岛素敏感性的影响。方法：灌服黄连素前后采用葡萄糖－胰岛素耐量试验测量大鼠胰岛素敏感性（Ｋ值），并测量空腹血糖、胰岛素、血脂及肌肉中甘油三酯（ＴＧ）含量等。结果：１个月后，高脂饮食对照组的空腹血糖、胰岛素、血脂、肌肉中ＴＧ高于正常对照组，而肝糖原减少，胰岛素敏感性下降（Ｋ值５．０２±１．０８，与正常对照组８．７２±０．９１比较，Ｐ＜０．００５）。用黄连素、二甲双胍治疗１个月后，其胰岛素敏感性改善，Ｋ值分别为６．３１±０．９５、６．２４±０．６５。肝糖原升高（Ｐ＜０．０５），但空腹血糖、胰岛素、血脂、肌肉中ＴＧ浓度相似。结论：高脂饮食能造成大鼠明显胰岛素抵抗模型，黄连素有与二甲双胍相似的增加胰岛素敏感性作用。 |
| 英文摘要: |
| To observe the effects of berberin on insulin sensitivity in high fat diet rats. Methods: Before and after ingesting berberin, glucose insulin tolerance test was used to measure the insulin sensitivity, and determining fasting blood glucose, insulin, blood lipid and muscle triglyceride content. Results: Compared with normal feeding rats, high fat feeding impaired insulin action (5. 02 ±1. 08 vs 8. 72± 0. 91, P<0. 005), decreased liver glycogen level and raised fasting blood glucose, insulin and blood lipid levels. Berberin and metformin improved insulin resistance (6. 31 ± 0. 95 and 6. 24± 0. 65) and liver glycogen level in insulin resistance models, but had no effect on blood glucose, insulin, lipid levels and muscle triglyceride depots. Conclusion: It is confirmed that berberincould raise insulin sensitivity of high fat diet rats similar to metformin. |
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