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高从容,张家庆,黄庆玲.黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究[J].,1997,(3):162-164
黄连素增加胰岛素抵抗大鼠模型胰岛素敏感性的实验研究
Experimental Study on Berberin Raised Insulin Sensitivity in Insulin Resistance Rat Models
  
DOI:
中文关键词:  黄连素  二甲双胍  胰岛素敏感性  胰岛素抵抗
英文关键词:berberin  metformin  insulin sensitivity  insulin resistance.
基金项目:
Author NameAffiliation
高从容 第二军医大学长海医院内分泌科 
张家庆 第二军医大学长海医院内分泌科 
黄庆玲 第二军医大学长海医院内分泌科 
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中文摘要:
      目的:观察黄连素对高脂饮食大鼠胰岛素敏感性的影响。方法:灌服黄连素前后采用葡萄糖-胰岛素耐量试验测量大鼠胰岛素敏感性(K值),并测量空腹血糖、胰岛素、血脂及肌肉中甘油三酯(TG)含量等。结果:1个月后,高脂饮食对照组的空腹血糖、胰岛素、血脂、肌肉中TG高于正常对照组,而肝糖原减少,胰岛素敏感性下降(K值5.02±1.08,与正常对照组8.72±0.91比较,P<0.005)。用黄连素、二甲双胍治疗1个月后,其胰岛素敏感性改善,K值分别为6.31±0.95、6.24±0.65。肝糖原升高(P<0.05),但空腹血糖、胰岛素、血脂、肌肉中TG浓度相似。结论:高脂饮食能造成大鼠明显胰岛素抵抗模型,黄连素有与二甲双胍相似的增加胰岛素敏感性作用。
英文摘要:
      To observe the effects of berberin on insulin sensitivity in high fat diet rats. Methods: Before and after ingesting berberin, glucose insulin tolerance test was used to measure the insulin sensitivity, and determining fasting blood glucose, insulin, blood lipid and muscle triglyceride content. Results: Compared with normal feeding rats, high fat feeding impaired insulin action (5. 02 ±1. 08 vs 8. 72± 0. 91, P<0. 005), decreased liver glycogen level and raised fasting blood glucose, insulin and blood lipid levels. Berberin and metformin improved insulin resistance (6. 31 ± 0. 95 and 6. 24± 0. 65) and liver glycogen level in insulin resistance models, but had no effect on blood glucose, insulin, lipid levels and muscle triglyceride depots. Conclusion: It is confirmed that berberincould raise insulin sensitivity of high fat diet rats similar to metformin.
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