| 姜文卿,刘秀杰,陶寿淇,李介鸣,赵淑华,郭秀珍.附子1号的临床研究[J].中国中西医结合杂志,1981,(1):6-8,61,67 |
| 附子1号的临床研究 |
| Clinical Study of the Effect of Higenamine on Ejection Fraction and Bradyrhythmia |
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| DOI： |
| 中文关键词: 附子 异丙肾 房室传导阻滞 临床研究 缓慢性心律失常 窦房阻滞 左心功能 左室射血分数 核听诊器 心率 |
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| 摘要点击次数: 1376 |
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| 中文摘要: |
| 附子1号注射液,为中国医学科学院药物研究所合成的一种新的活性成分消旋去甲乌药硷(dl-Demet-hyl-Coclaurine 即 Higenamine),临床对缓慢性心律失常的作用,已有报告。为探讨该药对左心功能的影响,我们采用核听诊器以113 m 铟测定左室射血分数(LVEF),同时对传导阻滞、心率、血压以及 |
| 英文摘要: |
| Higenamine,dl-Demethylcoclaurine,an active principle of Strobal found experimentally to have an action similar to isoproterenal,was studied in 19 patients with sick sinus syndrome,8 patients with second degree and 2 cases with third degree atrioventricular(AV)block.Higenamine was administered by intravenous drip at a rate of 12.5 to 50 μg per min.Left ventricular ejection fraction(LVEF),which was determined in 15 patients by using nuclear stethoscope and 113~m In.,increased from an average of 45.7±9.7 to 63.3±13.9%(P<0.001).Isoproterenal given to 6 of the patients at a rate of 0.5 to lμg per min.caused an increase of LVEF from an average of 55.7 ±8.0 to 78.2±7.0%.Significant difference was found in the percentage increase of LVEF produced by the two drugs(P<0.001).During the administration of Higenamine the heart rate increased from an average of 54.0 to 71.0 beats/min.in 4 cases of sinus bradycardia.Sino-atrial block disappeared in 1 of the 4 cases of AV junctional rhythm.Sinus rhythm appeared in 3 cases and the heart rate increased from an average of 44.3 to 64.3 beats/min.In the other cases.the rhythm was unchanged.Side effects:ventricular premature beats and anesthesia of tongue. |
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