联苯双酯及水飞蓟蜜丸治疗慢性病毒性肝炎临床疗效观察

作者	单位
张育轩	中国医学科学院首都医院中医科
于惠钦	中国医学科学院首都医院中医科
史济招	中国医学科学院首都医院中医科

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中文摘要:

五味子治疗肝炎具有较明显的降血清谷丙转氨酶(以下简称谷丙酶)效果,及其对实验性肝损伤具有一定程度的保肝作用,已屡见于文献报道。虽然对其治疗慢性肝炎的评价尚有争议,但它仍是目前临床常用的治疗肝炎尤其是降谷丙酶的有效药物之一,惟由于药源不足及药物本身的酸味可能引起胃部不适,

英文摘要:

Biphenyl Dicarbosylate was given to 93 cases of chronic viral hepatitis(C.P.H.and C.A.H.).The drop in serum SGPT was quite obvious.The markedly effective rate was 78.42%.The effective rate was 90.32%.These values were much higher than those of Honey-pilula of Silybum Marianum(L.)Gaertn,which were 14.29% and 21.43% respectively. The effect was obtained within one month of treatment.The drop in serum SGPT was immediate,regardless of the duration of illness or positive or negative HBsAg.The initial observations reveal that the effective dose is 150mg daily.But 75mg daily has also produced a positive effect. The effect of Biphenyl Dicarbosylate for treatment of chronic hepatitis seemed to be reflected also in the improvement in AKP,αFP,prothrombin activity and serum bilirubin. In quite a number of cases appetite improved,and the distension of abdomen and loose bowel movement were relieved after treatment. The effect of Biphenyl Dicarbosylate as indicated by TTT and TFT,the change from HBsAg(+)to HBsAg(-),the diminution of splenomegaly and hepatomegaly proved unsatisfactory. The foward effect of biphenyl Dicarbosylate was not stable.Among the cases with marked effect,relapses within one year after the course of treatment were 65.85%.But the level of serum SGPT was never so high as that before the treatment.Moreover,repeated administration of Biphenyl Dicarbosylate produced a therapeutic result which was just as effective.It seems possible to obtain the stability of the therapeutic effect,if the period of the administration of Biphenyl Dicarbosylate is prolonged.

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