| 邱洪法,陈文为,薛延,贾维维.气血实质的探讨——Ⅰ.四种中药和生脉液对鼠肝线粒体(体外)氧化磷酸化的影响[J].中国中西医结合杂志,1981,(1):32-35,64 |
| 气血实质的探讨——Ⅰ.四种中药和生脉液对鼠肝线粒体(体外)氧化磷酸化的影响 |
| Studies on the Nature of Oi(vital)and Xue(blood):The Effects of 4 Kinds of Chinese Medicinal Herbs and Shen Mai Ye on Rat Liver Mitochondrial Oxidative Phosphorylation,in vitro |
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| DOI： |
| 中文关键词: 生脉液 氧化磷酸化作用 鼠肝线粒体 线粒体能量代谢 生物能学 五味子 耗氧量 祖国医学 呼吸控制率 人参 |
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| 中文摘要: |
| 线粒体是细胞一个重要的细胞器,它通过"呼吸"作用为生命活动提供必要的能量。而生物能是维持机体生命的重要物质基础,所以,能量代谢是人体物质代谢的最基本形式。它包括:能量的生成、利用、转换、储存和调节等环节,构成了近代生物能学。近代生物能学与祖国医学中"气"的学说不尽相同。祖国医学认为"气者,人之根本也。"(《难经·六 |
| 英文摘要: |
| Vital energy is an essential material for life,and is known to have its source from glycolysis and oxidation phosphorylation,of which the latter is more important,production of energy is in close relation with the consumption of oxygen by mitochondria. The authors applied the water extracts of 4 Chinese medicinal herbs（Panax ginseng,Angelica sinensis, Astragalus mongholicus and Schizandra chinensis）and an injection of Sben Mai Ye,which possesses a Qi-reinforcing quality,and studied their effects on rat liver mitochondrial oxidative phosphorylation in vitro. The results showed that these herb water extracts inhibited the oxygen consumption（S3）and decreased ADP/ O ratio in different degrees.The extract of panax ginseng reduced the oxygen uptake most obviously.Injection of Shen Mai Ye inhibited S3 oxidation,stimulated S4 oxidation,decreased ADP/O and respiratory control index （RCI,S3/S4）.The prescription Shen Mai Ye and Panax ginseng could act as an modulating uncoupler.The uncoupling of oxidative phosphorylation can be biologically useful,since it is a means of generating heat to maintain body temperature,which enables the body to adapt itself to cold or pathologic condition. |
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