| 邝安堃,龚兰生,丁霆,陈家伦,许曼音,丁怀翌,张达青,蔡宜生,罗素珍,汪关煜,张美云,陈梦月,王文娟,杨永华.冠心病中血浆雌二醇、睾酮的变化及中药治疗的影响[J].中国中西医结合杂志,1982,(1):13-14,61 |
| 冠心病中血浆雌二醇、睾酮的变化及中药治疗的影响 |
| Plasma Estradiol and Testosterone Concentrations in Patients with Coronary Artery Disease and the Effect of Treatment with Chinese Medicinal Herbs |
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| DOI： |
| 中文关键词: 女性冠心病 中药治疗 性激素 血浆雌二醇 雌激素 人血浆 冠心病人 心肌梗塞后 中医辨证 发病关系 |
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| 中文摘要: |
| 冠心病的发病原理迄今未阐明,一些病人并无常见的易患因素,也发生了冠心病。近年报道年龄较轻的男性冠心病人血中雌激索增高,提出了性激素环境和冠心病发病关系.两年来我们对此问题进行了探索,研究的目的是,1.男性冠心病人血浆雌二醇、睾酮及二者比值的变化。2.中医辨证和性激素之间的关系;3.以"治本"为主的中药对冠心病的疗效及其对血浆性激素的影响。现报道所获得的初步结果。 |
| 英文摘要: |
| 25 cases of coronary artery disease（20 males,5 females）were treated by Chinese medicinal herbs （Nitroglycerine was given sublingually during anginal attacks）.According to the diagnosis by TCM,22 cases had either"Yang Xu"（阳虚）or"Qi Xu"（气虚）,and 3 cases had both"Qi Xu" and"Ying Xu"（阴虚）,with "Ying Xu"predominant.17 male patients had manifestations of"Xu"in the"Kldney",such as impotence, lumbago,weakness of legs,tinnitus and dizziness.4 bad also gynecomastia. In 18 male patients（average age 66 years）,the plasma estradiol（E2）and testosterone（T）concentrations and their ratio（E2/T）were determined before and after the treatment.The plasma levels of 30 normal males aged over forty were also measured and served as controls.In addition,the plasma E2,T levels and E2/T ratio of 8 cases of acute myocardial infarction were measured in the third week of hospitalization.Before the treatment,the mean plasma concentrations of E2 and T in the 18 male patients were 108.17±11.23 pg/ml（±SE）and 683.89±66.73 ng/100ml respectively,with a E2/T ratio of 0.018±0.0023.After the treatment,mean E2 decreased to 56.33±6.60 pg/ml（P<0.01）,mean T did not change significantly with a value 680.39±54.70 ng/100ml （P>0.05）and the E2/T ratio decreased to 0.0085±0.00076（P<0.01）.As a result of the treatment,symptoms such as intolerance to cold,coldness of extremities,lumbago,weakness,etc.showed varying degrees of improvement in most patients,and the frequency of angina decreased markedly.There was no significant change in the plasma sex hormone concentrations in the 8 patients with acute myocardial infarction. The results of the present study show that male patients with angina due to coronary artery disease and manifestations of"Xu"in the"kidney"have elevated plasma.E2 concentration and increased E2/T ratio.After the treatment by Chinese medicinal herbs,these increases can be significantly brought down along with a decrease in the frequency of anginal attacks and an improvement of the plasma sex hormones may represent biological indicators of"Xu"in the"Kidney"in terms of the TCM. |
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