益气、活血方药对冠心病临床疗效观察

作者	单位
廖家桢	北京中医学院东直门医院内科气血研究室
武泽民	北京中医学院东直门医院内科气血研究室
康廷培	北京中医学院东直门医院内科气血研究室
史载祥	北京中医学院东直门医院内科气血研究室
郭鲁之	北京中医学院东直门医院内科气血研究室
孙塑伦	北京中医学院东直门医院内科气血研究室

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中文摘要:

本文对35例冠心病住院患者,先后交替静脉点滴益气液(26例次)、活血液(35例次)及益气液与活血液同用(19例次),各用药2周。采用单盲、自身先后对照的方法观察了对冠心病心绞痛的近期临床疗效。结果是心绞痛症状及心电图的总有效率分别为:益气组76.19%、19.24%;活血组85.71%、60%;益气活血组76%、43.26%。三组间心绞痛症状的总有效率无明显差异;心电图的总有效率益气组低于活血组及益气活血组。

英文摘要:

35 patients with coronary heart disease were studied to compare the effectiveness of Yiqi (益气,reinforcing the vital energy),Huoxue(活血,invigorating blood circulation)and Yiqi- Huoxue therapeutic methods in the treatment of angina pectoris(single blind).The therapeutic procedures were as follows:(1)All 35 cases(Yiqi group)received Yiqi injection 10ml daily (consisting of three Chinese herbal medicines).(2)Five days after the course of Yiqi therapy, 26 of 35 cases(Huoxue group)received Huoxue injection 10ml daily(consisting of three Chinese herbal medicines).(3)Five days after Huoxue therapy,19 of 35 cases(Yiqi-Huoxue group)also received both Yiqi and Huoxue injection,each 10ml daily.Every therapeutic method was given intravenously for 2 weeks.The results are as follows. The effective rate for angina pectoris was 85.71% in Huoxue group,76.19% in Yiqi group, and 75% in Yiqi-Huoxue group.The difference among the three therapeutic groups was not of statistical significance(P>0.05).The effective rate for ischemic ST-T changes was 60% in Huoxue group,which was significantly higher than 19.24% in Yiqi group(P<0.05),but the difference between Huoxue group and Yiqi-Huoxue group(43.3%)was not of statistical significance(P>0.05).The rate of ST-T segment deterioration after treatment was higher in Yiqi group(34.61%)than that in Huoxue group(11.43%,P<0.01),but the difference between Yiqi and Yiqi-Huoxue group was not statistically significant(P>0.05).All these findings suggest that the therapeutic efficacy was better in Huoxue group as compared to the other two groups.The authors point out that the mechanism of the S-T segment deterioration in Yiqi group needs further research.It might be caused by pharmacologic influence of the drug on the myocardium rather than by a deterioration of myocardial ischemia,since the pattern of change in S-T segment after Yiqi treatment was similar to the characteristic effect of digitalis on ECG.

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