丹参注射液对骨折愈合中钙沉积的影响

作者	单位
张菊英	上海市伤骨科研究所基础理论研究室
刘季兰	上海市伤骨科研究所基础理论研究室
柴本甫	上海市伤骨科研究所基础理论研究室

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中文摘要:

本文通过⁴⁵Ca—液闪测定,观察正常小鼠股骨及胫骨⁴⁵Ca 沉积的情况及丹参对小鼠右股骨中段骨折后⁴⁵Ca 沉积的影响。发现正常小鼠、左右骨相应部位钙沉积相似:右股骨中段骨折后,生理盐水组与丹参组小鼠的中段股骨钙沉积不断升高,而股骨上、下二段反而下降,丹参组下降更显著。说明丹参可以从郇近骨组织中调动比生理盐水组更多的钙,以更好地满足新骨形成对钙的需要,从而使骨折愈合加速。

英文摘要:

⁴⁵Ca deposition in the femur and tibia of normal mice and the effect of Radix Salviae Miltiorrhizae on ⁴⁵Ca deposition following fracture of the right middle femur were studied in three groups of mice,totalling 54 in number. 1.Normal group:The upper,middle and lower thirds of the left and right femora showed identical calcium deposition rates with highest value in the lower thirds.The calcium deposition rate was highest in the upper third of the tibia. 2.Fracture-saline group:Following standardized fracture of the right middle femur,deposition of calcium in the middle third increased considerably throughout the experiment（5,7,9,13 post-fracture days） and showed high statistical significance as compared with the corresponding values in the normal group. This shows that in keeping with the new bone formation in the fracture region,there was massive deposition of calcium salts.On the contrary,the calcium deposition in the upper and lower thirds of the femur and in the tibia decreased significantly as compared with the corresponding values in the normal group.This shows that the bone tissue adjoining the fracture region provided calcium to meet the increased demand in the callus formation through a decrease in deposition or an increase in absorption of calcium. 3.Fracture-Radix Salviae Miltiorrhizae group.Following the fracture of the right middle femur and the administration of Radix Salviae Miltiorrhizae,the increase in calcium deposition of the middle third of the right femur continued,while the decrease in calcium deposition in the upper and middle thirds of the right femur and in the tibia was aggravated.This clearly manifests that Radix Salviae Miltiorrhizae could transfer more calcium from the bone tissue adjoining the fracture region than it did in the saline group,so as to meet the increased need of calcium for the callus.Thus fracture healing could be expedited.

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