马桑内酯治疗精神分裂症并用抗癫痫药对抗抽搐副作用的研究

作者	单位
胡光才	四川医学院精神病学研究室
刘协和	四川医学院精神病学研究室
叶孝贤	四川医学院精神病学研究室
张运惠	四川医学院精神病学研究室
邹文韵	四川医学院精神病学研究室

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中文摘要:

马桑寄生的提取物马桑内酯治疗精神分裂症有效,因其致抽搐作用临床使用受到限制。本文试用苯妥英钠等抗癫痫药对抗马桑内酯致抽搐作用,获得显著效果。对照观察表明,治疗中抽搐被控制后其疗效不受影响。

英文摘要:

Lactoni coriariae,an extract from Chinese herbs Coriariae parasiticus and Coriariae,has been used for the treatment of schizophrenia and its clinical effect proved.But this drug has epileptogenic side-effect,and fractures caused by induced seizures can be occasionally seen during the treatment. In this study,anticonvulsants such as sodium dilantin or primidone were used for the control of induced seizures during treatment of schizophrenia with lactoni coriariae.Sodium ditantin 0.2 tid or primidone 0.5 tid was used as premedication 6-10 days before the coriariae therapy.In some cases,sodium dilantin 0.2 was administered intramuscullarly as an extrapremedication prior to coriariae treatment.Results of this study showed that anticonvulsants used in the coriariae therapy could decrease the average occurrences of seizures from 1.98 to 0.72 per session,and the occurrences of non-seizure sessions in the total group of patients under treatment increased from 22 to 48. Spitzer’s"Schedule for Affective Disorders and Schizophrenia".was used for diagnosis and selection of schizophrenic patients in this study,90 schizophrenic patients were selected and randomly divided into 3 groups:convulsive group,anticonvulsive group and control(chlorpromazine)group,in these 3 groups,27,23 and 21 cases fulfilled the requirements of this study respectively.At the end of the study,in the convulsive group,48.1% of the cases improved and 22.2% markedly improved;in the anticonvulsive group 56.5% of the cases improved and 30.4% markedly improved;in the control group,66.7% of the cases improved and 52.4% markedly improved.The therapeutic effect in the anticonvalsive group was slightly higher than that in the convulsive group,but slightly lower than that in the control.The differences of therapeutic effect between these 3 groups were insignificant.These findings have shown that lactoai conariae is effective in the treatment of schizophrenia,its epileptogenic effect could be significantly minimized by anticonvulsants,yet its clinical effect would not be lowered.

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