慢性胃炎中医脾、肾虚证尿胃蛋白酶和17-OHCS测定结果分析

本文测定了75例慢性胃炎病人和21例正常人日、夜尿胃蛋白酶和17-OHCS,结果表明:脾虚或肾虚胃粘膜主细胞和肾上腺皮质功能的昼夜节律与正常人相似。脾虚病人,这两个指标较正常人变化不大,提示机体处于代偿阶段。脾肾虚病人,这两个指标均显著低于正常人,说明机体已失代偿。尿17-OHCS 与胃蛋白酶存在一定的正相关关系,反映肾阳对脾胃的影响。

英文摘要:

This paper reports a preliminary research into the role of spleen and kidney deficiency in chronic cases of gastritis by determining contents of pepsin and 17-OHCS in urine excreted in day and night.The results obtained show that in patients with chronic gastritis,with either spleen or kidney deficiency,the chief cells in gastric mucosa and adrenal cortex can function with diurnal rhythem as in normal subjects. The fact that chief cells in gastric mucosa and adrenal cortex,and their regulating system showed little difference as compared with those of normal subjects may be explained by effective compensation of the human organism.However,the pepsin and 17-OHCS contents in urine excreted by the patients with spleen and kidney deficiency in day and night and 24 hours are significantly lower than those of the normal subjects,which indicates that the organisms are in a stage incapable of compensation.This finding shows that the theory"protracted disease impaires the kidney"in TCM has its material basis. Meantime,the statistical relationship between 17-OHCS and pepsin is a plus correlation reflecting the influence of kidney-Yang on the functioning of the spleen and stomach.

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