中医阴阳的实验性研究(Ⅳ)  附子、肉桂和六味地黄方对肾血管性高血压大鼠心肌的作用

Experimental Research of Yin-Yang theory in TCM(Ⅳ)Effect of Mankshood,Bark of Chinese Cassia Tree and Liu Wei Di Huang Fang on Myocardium of Renovascular Hypertensive Rats

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中文关键词: 六味地黄方肾血管性高血压大鼠实验性研究附子高血压模型羟脯氨酸心脏肥厚六味地黄汤心肌肥厚助阳药

英文关键词:

基金项目:

作者	单位
邝安堃	上海市高血压研究所
顾德官	上海市高血压研究所
张维忠	上海市高血压研究所
顾天华	上海市高血压研究所
沈家麒	上海市高血压研究所

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中文摘要:

实验证实二肾一夹型高血压大鼠心肌肥厚伴有左室壁羟脯氨酸浓度明显增加,并发现助阳药附子加剧这种改变,而滋阴药六味地黄方则减轻这种改变。六味地黄方降低心肌羟脯氨酸浓度,间接提示减少心肌胶原的沉着作用,这可能为该方防治心血管损害提供一定依据。由助阳药和滋阴药对该模型羟脯氨酸浓度的相反作用,可推想二肾一夹型高血压可能为中医的"阴虚"模型。

英文摘要:

This study confirmed cardiac hypertrophy of the two-kidney one-clip Goldblatt hypertensive rats with high hydroxyproline level in the left ventricular wall.we found that mankshood of Yang-tonifying drug further increased the hydroxyproline level while Liu Wei Di Huang Fang(Prescription of Six Drugs with Rehmannia:Radix Rehmanniae,Praeparata Fructus Corni,Rhizoma Discoreae,Cortex Moutan Radicis,Rhizoma Alismatis and Poria)of Yin-nourishing drug decreased its level.Mankshood was found to act on cardiac hypertrophy like adrenaline,which might be explained by its ability to elevate myocardial hydroxyproline level.However,Liu Wei Di Huang Fang decreased myocardial hydroxyproline content,and thus indirectly reduced the deposition of myocardial collagen.Therefore,Liu Wei Di Huang Fang might serve as a means to prevent and treat cardiovascular lesions caused by hypertension. We have demonstrated in this and the precedent paper that in the renovascular hypertensive rats,the action of drug Yang(mankshood root)and that of the drug Yin(Liu Wei Di Huang Fang)have an opposite effect on cardiac hydroxyproline and brain tissue enkephalin level,the drug Yang having a deteriorative while drug Yin a beneficial effect.The drug Yang elevated the hydroxyproline and lowered the enkephaline level.The drug Yin lowered the hydroxyproline and elevated the enkephaline level.These results suggested that these renovascular hypertensive rats model might serve as a Yin Xu model(Yin deficiency model). This finding confirms our previous belief that drug Yang and drug Yin,by their opposite effect,can determine whether an experimental model is Yang Xu(Yang deficiency)or Yin Xu(Yin deficiency).It might also be applied to human diseases.

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