结石阻塞总胆管后胆道运动功能变化的实验观察

实验方法取体重2.5～3kg 家兔,禁食16小时后局麻下进行手术。打开腹腔后找到总胆管,其直径为2～3mm。自总胆管前壁切一小口,将略大于总胆管直径的无菌砂粒一块送入总胆管末端。然后于此小切口处置入一直径略小于总胆管直径的"T"型管。此管与临床使用者相同,即保持胆流的通畅,又能进行压力变化动态观察。缝闭此小切口,再自胃窦部切一小口置入一导管,经幽门送达十二指肠以便灌注药物应用。缝合胃造口处,将上述二导管引至腹壁外后关

英文摘要:

In a series of experiments upon the rabbits,it was found that a strong contractive activity occurred in an obstructed common bile duct with stones.In this study,some medicinal influences upon intraluminal pressure within the common bile duct and its wave variation were observed by inserting an open-end"T"tube which was connected to pressure transducers,and the output was recorded on a polygraph.The baseline pressure,frequency, wave length and wave height were compared before and after the infusion of medicine.The results showed that prostigmine and Artemisia capillaris increased the biliary pressure and promoted the activities of the sphincter choledochus;654-2 and atropine stopped the wave for 2-12 min;rhubarb,mirabilite and magnesium sulfate reduced the frequency.With regard to these medicinal influences,there are some differences between the obstructed biliary tract and the normal.The co-authors have observed the tracing of stone evacuation.Further investigation is expocted.

关闭