沈惟堂,高玉娥,徐凤飞,段恕诚,袁曼,童华华,徐肇玥,戴自英.山莨菪碱对内毒素休克犬血清β-葡萄糖醛酸苷酶活力的影响[J].中国中西医结合杂志,1985,(9):561-562,517 |
山莨菪碱对内毒素休克犬血清β-葡萄糖醛酸苷酶活力的影响 |
Effect of Anisodamine on Serum β-Glucuronidase Activity in Shock |
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DOI: |
中文关键词: 内毒素休克 酶活力 葡萄糖醛酸苷 山莨菪碱 组织细胞 抗休克 酸性磷酸酶 血清 溶酶体酶 血压 |
英文关键词: |
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中文摘要: |
血清β-葡萄糖醛酸苷酶活力的高低,可反映组织细胞受损的程度。本组实验动物注射内毒素造成休克后,血清β-葡萄糖醛酸苷酶活力升高明显,且随着休克时间延长,活力增高愈为明显。654-2(山莨菪碱)治疗组动物β-葡萄糖醛酸苷酶活力增高幅度较小,此结果提示654-2具有明显的抗休克作用。 |
英文摘要: |
The effect of anisodamine on serum β-glucuronidase activity in shock is reported.It was well established that serum level of β-glucuronidase increased under various states of shock and the changes of this enzyme in serum could reflect the degree of cellular damage. Experiments were carried out on mongrel dogs in shock produced by injected endotoxin.Obvious rise in serum level of β-glucuronidase was observed.The longer the shock lasted,the higher did β-glucuronidase activity become. Our results showed that the level of serum β-glucuronidase activity was lower in the group treated with anisodamine than in the shock group. The results obtained in the present study indicate that anisodamine can improve cellular damage by way of relieving vasoconstriction and improving microcirculation.Other mechanisms remain to be elucidated. |
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