慢性胃病脾虚证转归中血浆环核苷酸、~3H-TdR淋巴细胞转化的量变和作用——兼论阴阳学说的物质基础

A Study of ~3H-TdR Lymphocyte Transfer Value and Plasma cAMP and cGMP Level in Patients with Chronic Gastric Diseases due to Spleen Deficiency and Its Clinical Significance

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中文关键词: 淋巴细胞转化脾虚证阴阳学说慢性胃病脾气虚证脾虚气滞证物质基础血浆环核苷酸肠化生胃粘膜肠上皮化生

英文关键词:

基金项目:

作者	单位
尹光耀	无锡市第三医院临床医学研究室
虞佩英	无锡市第三医院临床医学研究室
周奚中	无锡市第三医院临床医学研究室
罗来蛟	无锡市第三医院临床医学研究室
唐静芬	无锡市第三医院临床医学研究室

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中文摘要:

本文动态观察51例慢性胃病脾虚证患者血浆环核苷酸、~3H-TdR 淋巴细胞转化和胃粘膜肠上皮化生的变化。cAMP 在脾虚证演化中起主导作用;cAMP 与 cGMP 并无互为消长的关系,阴阳学说的现代概念应建立在整体条件下神经体液调节的正负反馈基础上,而不能简单地把 cAMP 与 cGMP 作为这个学说的物质基础。

英文摘要:

The relationship between the intestinal metaplastic changes and plasma cAMP and cGMP level and ~3H-TdR lymphocyte transfer rate in 51 cases of chronic gastric diseases with spleen deficiency has been observed.The cAMp level and ~3H-TdR lymphocyte transfer in patients with spleen deficiency were found lower than those in normal subjects(P<0.001).There was significant difference in these between patients with deficiency of spleen-energy and spleen deficiency with energy stagnation,between patients with or without metaplasia,between patients with severe or mild metaplasia,and between patients with spleen deficiency in a changing pr(?)cess(P<0.05～0.001).However, no marked alteration of plasma cGMP level was observed.All these findings suggest that cAMP might affect through its quantitative alteration the chronic gastric diseases with spleen deficiency changes and cell metabolism, atypical and cancerous changes in mucosa.The quantitative alteration of cAMP may serve as a means to regulate the cell immune capacity when cAMP is very low,cell immune capacity could be restricted;The regulating function of cGMP upon cell generation and cell immunity does not depend on its quantitative alteration.Therefore,cAMP and cGMP cannot be regarded as material basis of"Yin-Yang"theory.

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