中华猕猴桃多糖的免疫药理学作用

作者	单位
张菊明	浙江中医学院分子医学研究所
林佩芳	浙江中医学院分子医学研究所
何一中	浙江中医学院分子医学研究所
徐杭民	浙江中医学院分子医学研究所

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中文摘要:

中华猕猴桃根是一种中药材。本文报道了从它的根中提取的多糖复合物(简称 ACPS)对小鼠免疫系统的调节作用。小鼠每日腹腔注射 ACPS,1～2周后分别测定免疫功能。结果:(1)ACPS 能明显促进天然杀伤(NK)细胞对 YAC-1淋巴瘤细胞的细胞毒作用;(2)能加强巨噬细胞的吞噬功能;(3)能明显增加特异花结形成细胞(SRFC)数,但对抗体形成细胞(PFC)无任何影响;(4)能有效地恢复被环磷酰胺抑制了的迟发超敏(DTH)反应。上述结果表明 ACPS 是一种有效的免疫调节剂。这在机体抗病毒抗肿瘤中或许有重要意义。

英文摘要:

This paper reports the immunomodulatory action of the polysaccharide extracted from the root of Actinidia chinensis(ACPS).Mice were given ACPS daily intraperitoneally for 1～2 weeks,and their immune fanctions were examined.The results were as follows:(1)ACPS could significantly enhance the natural killer(NK)cellsat 10 and 13 days after administration.(2)It might enhance the phagocytic function of macrophages.(3)It could markedly increase the number of SRFC(specific rosette forming cell),but there was no change on antibody lorming cells at all. (4)It might actively restore the delayed-type hypersensitivity reaction from the suppression by cyclophosphamide. The above-mentioned results indicated that ACPS acts as an effective immunomodulating agent.It may probably be of great benefit for hosts to strengthen their anti-viral and anti-neoplastic activities.

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