泻热汤的实验研究

作者	单位
王家泰	北京友谊医院
王宝恩	研究生天津市第一中心医院
马纪平	研究生天津市第一中心医院
赵淑颖	研究生天津市第一中心医院

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中文摘要:

本文研究结果说明泻热汤可使实、验性感染发热之家兔肛温下降,效果优于硫酸镁、自来水组。豚鼠服泻热汤后,白细胞总数虽无显著变化,但嗜中性白细胞比例升高(P<0.01),吞噬功能增强;血清总补体水平有显著增高(P<0.05);血清之体外杀菌作用较未服泻热汤者增强。家兔行耳静脉注入内毒素,服泻热汤组于服后2、4小时,其内毒素阴转率较未服药组明显增高(P<0.025及0.005)。以上结果表明泻热汤有助于降温,提高机体防御能力并可对抗血清中的内毒素。

英文摘要:

Purgation method had been found very useful in treating acute infections,such as pneumonia, dysentery,acute pancreatitis and biliary infections,etc.Further experimental study was carried out in order to explore its mechanism.A Heat Purgating Mixture(HPM contains Rheum palmatum,Mirabilite, Scrophularia ninpoensis and Glycyrrhiza uralensis)as representative prescription was used.The result Showed that this mixture could lower the body temperature in animal models of acute infections,and its efficacy was better than that resulting from magnesium sulfate solution and water,P<0.05 and<0.01,It was observed that the ratio of PMN in blood and its phagocytic function,total serum complement activity could be raised by HPM,P<0.01 and<0.05.In vitro,the bacteriocidal effect of the serum obtained after administration of this mixture was stronger than the control.In rabbits given endotoxin intravenously,the normalization of endotoxemia was much easier when HPM was given.All these data indicated that the HPM is helpful in reducing the elevated body temperature,enhancing the host defence and counteracting endotoxemia.

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