山莨菪碱对内毒素休克狗心血管活动的效应

作者	单位
姚泰	上海医科大学基础医学部生理学教研室
肖永福	上海医科大学基础医学部生理学教研室
孙祥莺	上海医科大学基础医学部生理学教研室
童华华	华山医院传染病学教研室
袁曼	华山医院传染病学教研室
徐肇明	华山医院传染病学教研室
戴自英	华山医院传染病学教研室

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中文摘要:

给麻醉狗静脉注射大肠杆菌 O₁₁₁B₄内毒素5mg/kg 引起休克,60分钟后经股静脉注入山莨菪碱5mg/kg 后,可使心率加快,平均动脉压回升,左心室心肌收缩能力改善,肾血流阻力降低,肾血流量和尿量都增加。在对照组动物中仅给等容积的生理盐水,未出现上述变化。

英文摘要:

Experiments were carried out on-mongrel dogs anaesthetized with pentobarbital.Escherichia coli endotoxin(5 mg/kg)was given intravenously to produce circulatory shock.In 6 dogs,anisodamine(5 mg/kg)infused intravenously over a period of 60 min.caused increase in heart rate,left ventricular systolic pressure,positive and negative maximum dp/dt and mean arterial pressure.Renal blood flow and urinary outflow also raised.No such changes were observed in the control group of 6 animals which received saline infusion only.The results obtained indicate that anisodamine given at early stage of endotoxin shock improves myocardial contractility.

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