| 李国栋,陆钟琦.人参总皂甙对大鼠胰岛释放胰岛素的作用及其特点[J].中国中西医结合杂志,1987,(6):357-359,326 |
| 人参总皂甙对大鼠胰岛释放胰岛素的作用及其特点 |
| Effect of Ginseng Saponins on Insulin Release from Isolated Pancreatic Islets of Rats |
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| DOI： |
| 中文关键词: 胰岛素释放 大鼠胰岛 人参总皂甙 葡萄糖 肾上腺素 作用机理 异搏定 关系曲线 刺激 钙离子 |
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| 中文摘要: |
| 人参总皂甙本身可以刺激分离的大鼠胰岛释放胰岛素,并可促进葡萄糖引起的胰岛素释放。人参总皂甙与胰岛素释放之间的剂量—反应关系曲线呈"S"型。人参总皂甙对胰岛素释放的作用不依赖细胞外钙的存在,也不被肾上腺素所抑制,提示人参总皂甙对胰岛素释放的作用机理与葡萄糖不同。 |
| 英文摘要: |
| The effect of ginseng saponins on insulin release from isolated pancreatic islets of rats was studied.It was shown that ginseng saponins could stimulate insulin release from incubated or perifused islets and promote its release induced by highly concentrated glucose.When containing 2.8 mM glucose in medium which could not stimulate insulin release,the dose,response curve of correlation between ginseng saponins and insulin release displayed as"S"type,and the concentrations of ginseng sapomns which could cause the maximum insulin release was between 0.10 to 0.35 mg/ml.The effects of ginseng saponins on insulin release at different glucose concentrations were not significantly affected by adding 55 μM verapamil to prevent the influx of Ca++into the pancreatic cells or depriving Ca++in solution,showing that it was not dependent on extracellular calcium.Adrenaline（1 g/ml）could not inhibit insulin release induced by ginseng saponins from incubated or perifused rat islets.It was suggested that the mechanism of effect of ginseng saponins on insulin release was different from that of glucose. |
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