中西药分组治疗上消化道出血330例疗效观察

为评价大黄白芨粉、四黄汤、甲氰咪胍和止血芳酸对上消化道出血的临床疗效及剂型的优劣,本文观察了住院患者330例,并随机分为四组。其结果四组有效率无差异(P>0.05),均为有效的治疗药物,但在便隐血转阴平均天数中,两中药组优于两西药组,且有非常明显差异(P<0.01)。两中药组中,汤剂和粉剂无差异。四组对胃癌出血和食道静脉破裂出血病例均无效。

英文摘要:

In order to evaluate effects of Rheum officinale-Bletilla striata powder(RBP),Sihuang decoc- tion(四黄汤 Rheum officinale,Rehmannia glutinosa,Coptis chinensis and Astragalus mem- branaceus),cimetidine and PAMBA,330 patients with upper GI tract hemorrhage randomized into four groups were observed.The effective rate and the average time of negative conversion of occult blood in feces of RBP,Sihuang decoction,cimetidine and PAMBA were 97.1%(68/70)and 4.13±3.0 days,90%(90/100)and 3.51±1.54 days,98.9%(90/91)and 7.58±4.75 days,and 94.2%(65/69)and 6.66± 3.79days respectively.The differences in effective rates among 4 groups were not statistically significant(P>0.05).The differences of the time of negative conversion of occult blood between the two TCM groups(RBP and Sihuang decoction)or between the two WM groups(cimetidine and PAMBA)were also not statistically significant(P>0.05),but between TCM and WM groups,the differences were statistically significant(P<0.01).The effective rate of TCM groups were better than that of WM groups,and the side effect of the TCM therapy was fewer.Therefore these Chinese herbs could be used to treat upper GI tract bleeding,but when the GI bleeding was caused by gastric cancer,esophageal varix of liver cirrhosis and arteriosclerosis,etc,it should be treated carefully.

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