川芎嗪防治大鼠实验性肺水肿的电镜观察

作者	单位
戴顺龄	中国医学科学院基础医学研究所
苏树芸	中国医学科学院基础医学研究所
程凯	中国医学科学院基础医学研究所
邹宇宏	中国医学科学院基础医学研究所
薛全福	中国医学科学院基础医学研究所

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中文摘要:

本文论述川芎嗪对肾上腺素所致肺水肿预防与治疗作用的超微结构观察。肺水肿时可见间质腔与肺泡腔水肿,上皮细胞和内皮细胞肿胀、变性、脱落,基底膜裸露、断裂。而川芎嗪预防组和治疗组上述病变明显减轻,仅见间隔结缔组织增生,血管内皮、肺泡上皮细胞接近正常,与光镜观察及其他测定指标一致。

英文摘要:

The preventive effect of tetramethylpyrazine,an ingredient isolated from the Ligusticum wallichii,on pulmonary edema induced by adrenaline administration was observed in rats,and a positive efficacious result was obtained.The morphological change was observed by using electron microscope.It was found in pulmonary edema group that protein-rich fluid was filled in the alveolar and interstitial space.The endothelial and epithelial cells showed swelling,degeneration and necrosis.A part of cells broke away from the basement membrane which appeared uncovered and disintegrated.In the group prevented and treated by tetramethylpyrazine it was shown that all the damages alleviated,interstitial inflammation recovered,which induced proliferation of connective tissue.The results showed that tetramethylpyrazine could inhibit the increased pulmonary microvas- cular and alveolar permeability,cause the edema to disappear,and turn the alveolar epithelium and endothelium of blood vessel to be normal again.

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