| 严述常,曹望芳,张英华,李兰芳,余昌晏,朱章珊,胡静淑,吴晶新,巫善明,卓焕慈,吴国利,丛云辉,杨敏一,高丽珍,朱虹娟.猪苓多糖治疗慢性病毒性肝炎的临床和实验研究[J].中国中西医结合杂志,1988,(3):141-143,131 |
| 猪苓多糖治疗慢性病毒性肝炎的临床和实验研究 |
| Clinical and Experimental Research on Polyporus umbellatus Polysaccharide in Treating Chronic Viral Hepatitis |
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| 中文关键词: 慢性病毒性肝炎 实验研究 肝损伤 猪苓多糖 肝组织损伤 乙型肝炎表面抗体 治疗 临床与实验 修复作用 四氯化碳 |
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| 中文摘要: |
| 本文报告了猪苓多糖注射液的临床与实验研究结果。用随机抽样分组和双盲配对法治疗慢性病毒性肝炎359例,疗效显著,其特点为能显著地改善患者症状,降低谷丙转氨酶,抑制病毒复制（尤其是 HBeAg 阴转）,对肝组织损伤有修复作用,疗效较巩固,长期使用无毒副作用。药理实验表明,该药能减轻四氯化碳和 D-半乳糖胺引起的肝组织的病理损伤,促进肝损伤的恢复和肝脏的再生能力;促进豚鼠和熊猴乙型肝炎表面抗体的产生;使正常小鼠和肝损伤小鼠的腹腔巨噬细胞释放数和释放 H2O2能力明显增加。 |
| 英文摘要: |
| This article reports the clinical and experimental research on Polyporus umbellatus polysacchar- ide（PEP）injection.For five years,538 Cases of chronic viral hepatitis patients have been treated either with the PEP injection（359 cases）or with positive control（179 cases）in eight hospitals.The positive control included Salvia injection co.,Silimarin and intensive glycyrrhizin,etc.The clinical research,in which 40 pairs of patients were involved,was divided into two stages,the stage of randomized sampling test,from Feb.1981 to July 1985;and the stage of randomized pairing test, from July 1985 on.The results of both stages were identical with each other.After being treated with PEP injection,the symptoms were improved significantly;35.9% of the SGPT restored to the normal level with the total effective rate reaching 76.5%;38.6% of the HBeAg and 13.1% of the HBsAg converted negative;the titre of HBsAg decreased more than four times in 37.8% of cases,compared to that before the treatment.It was shown in the statistics of research data that there were significant differences between the injection group and the control.The pathologic lesions of liver tissue were much improved in 18 of 35 patients in various degrees.The therapeutic effects of the injection were stable according to the 2～4 year follow-up on part of the patients. In the animal experiments,it was indicated that the injection could lighten the pathologic lesions of liver tissue caused by CCl4 or D-galactose amine;stimulate the regeneration of liver cell on the newborn mice and the mice whose livers were partly resected;reduce the consumption of hepatog. lycogen on the mice with tumors or during hepatotoxication;stimulate the production of HBsAb in monkeys and guinea pigs who were infected by hepatitis B virus; inkrease the number of macro- phages and the amount of H2O2 secretion in the peritoneal cavities in normal mice and the mice with liver lesions caused by some chemotoxic substances. |
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