丹参对肝纤维重吸收的作用

作者	单位
马学惠	山西医学院肝病研究室
赵元昌	山西医学院肝病研究室
尹镭	山西医学院肝病研究室
韩德五	山西医学院肝病研究室
孙世荃	华北卫生研究所七所

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中文摘要:

在复合病因作用下,实验性大白鼠肝硬化形成后,停止病因刺激,经丹参注射液治疗3周后处死动物。在光镜及电镜下观察到,给药组动物肝内无纤维增生或仅有轻度纤维增生,而对照组动物仍呈明显肝硬化或重度纤维增生。肝内胶原蛋白含量,给药组明显低于对照组,尿羟脯氮酸排出量,则高于对照组。实验结果表明,丹参可促进已形成的胶原纤维降解,肝纤维重吸收。

英文摘要:

The liver of rats was developed cirrhosis induced by injection of CCl₄ and dietetic injury after 8 weeks.Then Salvia miltiorrhiza（SM）was given to a group,5 gm/kg body weight was injected subcutaneously once a day for 3 weeks.On the 43rd day all animals were sacrificed.The results indicated that the collagen content of the liver was lower in SM group（24.76 mg/g dry liver weight） than in the cirrhosis control（29.43 mg/g dry liver weight）.The urinary hydroxyproline content in SM treated rats were significantly higher（16.25r/ml）than those of the cirrhosis control（10.43r/ml）.Light and electron-microscopic study revealed that the fibrosis of liver were legs severe in SM group than in the control.There were no collagen fiber or only a little in the liver in 6 out of 8 rats in SM group, whereas 6 out of 8 were severe fibrosis and cirrhosis in the control.These results showed that SM could promote the collagen reabsorption,the collagen fiber of liver were decreased and urinary hydroxyproline excretion increased in SM group.

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