| 叶雪清,王荣光,张华严,吕肖峰,赵彦森,高晓坚,郭鹞,苏德争.棉酚治疗功能性子宫出血等病的临床观察和实验研究[J].中国中西医结合杂志,1988,(4):216-217,197 |
| 棉酚治疗功能性子宫出血等病的临床观察和实验研究 |
| Clinical Observation and Experimental Study of Gossypol in Treatment of Dysfunctional Menorrhagia,Endometriosis and Fibromyoma of Uterus |
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| DOI： |
| 中文关键词: 功能性子宫出血 棉酚 实验研究 组织形态 雌性大鼠 临床观察 子宫内膜异位症 高泌乳素血症 下丘脑 累积量 |
| 英文关键词: |
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| 摘要点击次数: 1312 |
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| 中文摘要: |
| 用棉酚治疗功能性子宫出血、子宫内膜异位症及子宫肌瘤共192例,收到较好疗效。观察了不同累积量棉酚对雌性大鼠的性生殖轴和生命重要器官的组织形态影响,及对性腺轴的内源性阿片肽和激素水平的影响。结果提示棉酚有兴奋和抑制的双相作用,且与累积量明显相关。适当使用或可作为诱导排卵、更年期人工绝经和治疗中度高泌乳素血症的药物。 |
| 英文摘要: |
| A total of 192 cases of dysfunctional menorrhagia,endometriosis and fibromyoma of uterus were treated with gossypol（20mg/day）for 3 weeks to 3 months or more with satisfactory results,the markedly effective rates were 91.5%,90.3% and 79.5% respectively.142 cases（74%）became amenorrheic,and the incidental rate varies with the accumulative amount of gossypol.Menstruation resumed after a period of 3～13 months of amenorrhea in 78 cases.Permanent amenorrhea resulted in 64 menopausal patients,and 10 of them have remained to be amenorrheic for over 5 years and enjoyed good health.400～1200 mg gossypol were given to 14 cases of dysfunctional menorrhagia （anovulatory type）with the result of the menstruation normalized with ovulation,suggesting a proper and smaller accumulative dosage might produce menstruation regulatory and/or ovulation stimulating effects.Further observation is necessary.Results of the present study showed that immediate and longterm effects displayed in the following order:dysfunctional menorrhagia,en- dometriosis and uterine fibromyoma,the longterm result of the latter was unsatisfactory.However, the use of gossypol for premenopausal fibroids of smaller size might bring beneficial therapeutic results.No persistent adverse side-effects have been noted during treatment. Animal experiments were carried out to explore the mechanism with following findings:（1）Rats receiving gossypol with accumulative dosis of 7 mg in a significant drop of Leucine-enkephalin and a marked increase of β-endorphin in the hypothalamus;plasma FSH and LH increased significantly with no change for the E2 and PRL.（2）Large dosis of 40～48 mg gossypot caused marked atrophic changes of both the ovaries and the uteri of rats.The suppressive effect on the hypothalamus- pituitary-gonadal axis appeared to vary directly with the dosage of drug administered.Acidophils of the anterior pituitary lessened or even disappeared completely while that of the basophils increased both in number and size resembling that of the so-called"postmenopausal cells".Plasma E2 diminished markedly and PRL was hardly detectable,suggesting that gossypol might be a valuable drug in treating the medium hyperprolactinemia.（3）Spontaneous remission of the above changes took place sooner or later following cessation of therapy.（4）No histological change was observed in the vital organs after medication. |
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