赤芍治疗肺心病的临床观察和防治肺动脉高压的实验研究

作者	单位
马秀凤	河南省医学科学研究所
马浩如	河南省医学科学研究所
钱翠萍	河南省医学科学研究所
王曙炎	河南省医学科学研究所
王和平	河南省医学科学研究所
王家邦	河南省医学科学研究所

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中文摘要:

本文报道用赤芍治疗30例肺心病代偿期患者。结果:¹¹³铟—MAA 肺灌注γ照相显示血运明显改善,心电图、心阻抗血流图显著改善,肺动脉平均压（PPA）和肺血管阻力（PVR）明显下降。心阻抗微分图和血液流变学指标均有显著好转。赤芍对实验性家兔肺动脉高压有治疗和预防作用,能扩张肺血管,改善肺血运状态,抑制血浆凝集和血栓形成,降低肺动脉压,增加心排量,改善心肺功能。

英文摘要:

This paper reported the results of clinical observation on treatment of pulmonary heart disease （compensatory stage）in 30 patients and experimental study in the prevention of puhnonary hyperten- sion with Paeonia lactiflora. Paeonia lactiflora-treated group received paeonia lactiflora extracturn 3g per day for three months.10 controls were treated by ordinary comprehensive therapy.The results showed that pulmonary artery perfusion restored to normal in 9 of 26 cases estimated by ¹¹³In-MAA γ- photograph.Mean pulmonary pressure（PPA）declined to normal in 4 out of 12 patients with pulmonary hypertension.The abnormal pulmonary impedance of 21 cases in 30 patients became negative.ECG signs were improved significantly.PPA and pulmonary vascular resistance（PVR） decreased.The stroke volume increased from 40.08 ml to 60.78 ml measured by cardiac impedance derivative method.Some indeces in hemorrheology were obviously improved.In the control group, no changes in the above indeces were found before and after treatment. Pulmonary hypertension models of 30 rabbits were made for experimental study.They were treated by IM injection of Paeonia lactiflora（1.0g/kg）and IM injection of Ligusticum chuanxong hort （20mg/kg）three times per week.After 6～7 weeks,PA in both groups declined to 9.97±2.53 cm H₂O and 12.56±2.62 cm H₂O respectively.CO returned to normal levels. Corresponding changes in histopathology of heart and lung were observed in this study.The results suggest that Paeonia lactiflora and ligusticum Chuanxong hort play a role in prevention of experimental pulmonary hypertension and the effects of Paeonia lactiflora are superior to ligusticum chuanxong hort.

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