大黄(庶虫)虫丸对实验性肝损伤的保护作用

作者	单位
邱培伦	西安医科大学药理教研室
袁素芬	西安医科大学第一附属医院传染病学教研室
舒昌杰	西安医科大学药理教研室
王美纳	西安医科大学药理教研室
刘俊田	西安医科大学药理教研室
王本兰	西安医科大学药理教研室
邓秀玲	西安医科大学药理教研室
王竹筠	西安医科大学药理教研室

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中文摘要:

用四氯化碳、乙醇综合法造成大白鼠慢性肝损伤,分组观察大黄（庶虫）虫丸的影响。结果给药组 LDH₅和 SGPT 降低,血清蛋白回升,γ-球蛋白下降,肝胶原明显减少,病理改变减轻,提示大黄（庶虫）虫丸对慢性肝损伤有保护作用。用四氯化碳造成急性肝损伤,分组观察,结果表明大黄（庶虫）虫丸对急性肝损伤无明显保护作用。

英文摘要:

27 rats were divided into three groups at random.Group 1,chronic hepatic injury model were given Dahuang Zhechong Pill（DZP）per os.Group 2,chronic hepatic injury model were given tap water.Group 3,normal rats,were only given tap water per os.By ninth week,all rats were sacrificed.The decrease of LDH₅,SGPT and γ-globulin,the increase of albumin and remarkable reduction of hepatic collagen were found in Group 1.The results indicated that DZP has protective effect on chronic hepatic injury.The other 30 rats were made acute hepatic injury models and studied with the above-mentioned way.The results indicated that DZP has no significant protective effect on acute hepatic injury.

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