| 邱佳信,杨金坤,唐莱娣,贾筠笙,曹棣芳,王楠,左建平,陈凤珠,高卫平,张文毅,李惠君,沈克平.健脾理气、清热解毒、软坚化痰中药对二乙基亚硝胺致大鼠肝癌的作用[J].中国中西医结合杂志,1988,(12):734-735,710 |
| 健脾理气、清热解毒、软坚化痰中药对二乙基亚硝胺致大鼠肝癌的作用 |
| The Effect of "SRRS" Recipe on the Formation of Rat Liver Cancer |
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| DOI： |
| 中文关键词: 二乙基亚硝胺 大鼠肝癌 清热解毒 中药 软坚化痰 健脾理气 显著差异 病理变化 大鼠肝脏 西药对照 |
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| 中文摘要: |
| 在二乙基亚硝胺诱发大鼠肝癌的过程中测定肝内酶 ACT、γ-GT、OCT、CPS1以及 AKP,并作病理检查,观察灌喂健脾理气、清热解毒、软坚化痰方剂的中药组、西药组（Vit.C+Vit.E+Vit.A）和对照组的酶以及病理变化。结果:对照组在致癌过程中 AKP、ACT、γ-GT 增高,而 CPS1、OCT 下降,中药能改变这种情况。西药组与中药组γ-GT、ACT、CPS1存在显著差异（P<0.05）。病理证实:肝组织脂变、纤维间变、假小叶形成等变化以对照组最严重、西药组次之,中药组最轻。 |
| 英文摘要: |
| 30 rats were divided into three groups.The TCM group was fed with"SRRS"recipe.The WM group was fed with vitamin A,E and C.The control group was fed with water.In the process of formation of rat liver cancer induced by Diethylnitrosamine,the action of some enzymes of the liver （ACT,γ-GT,OCT,CPS1 and AKP）were determined and pathologic examinations were done at intervals.The results showed that AKP,γ-GT,ACT were prominently increased and CPS1,OCT were notably reduced in the process of the hepatocarcinogenesis in the control,but these phenomena can be changed in the TCM group.In the WM group.AKP and OCT were the same as the TCM group,but γ-GT,ACT and CPS1 were different between these two groups（P<0.05）.The results of pathologic examination indicated that the change in the control group was most serious,while those in the WM group were moderately serious and those in the TCM group were not serious at all,no matter what they were fatty degeneration,fiber sepium,regeneration or inflammation infiltration, etc.It is suggested that the TCM not only can influence the process of formation of liver cancer induced by diethylnitrosamine but also was more effective than some WM group（vitamin A,E and C）. SRRS recipe:The recipe for strengthening the Spleen,regulating the Qi（气）,removing the toxic heat and softening the hard lumps and resolving the Phlegm. |
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