雷公藤治疗实验性变态反应性脑脊髓炎的病理组织学观察

作者	单位
李春光	解放军251医院病理科
李贵和	解放军251医院病理科
刘向清	解放军251医院病理科
陈恒年	解放军251医院神经科
李冲月	解放军251医院神经科

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中文摘要:

用雷公藤治疗豚鼠实验性变态反应性脑脊髓炎,以病理组织学和酶组织化学的方法观察其治疗作用。结果表明:治疗组炎症反应、神经纤维轴索的肿胀断裂及神经细胞坏死检出率显著低于对照组(P<0.01～0.005);神经纤维脱髓鞘治疗组低于对照组(P<0.025),酸性α—萘酚醋酸酯酶、碱性磷酸酶染色证实脊髓中浸润的淋巴细胞为 T 淋巴细胞。雷公藤能够抑制细胞免疫反应,从而减轻了治疗组的病变和阻止了病变的发生。

英文摘要:

The Tripterygium wilfordii(TW)was used to treat experimental allergic encephalomylitis(EAE) in guinea-pig.The morphological change was observed by using light microscope.Lymphocytic histochemical staining was performed on the spinal cord from EAE in guinea-pig.The results were: The incidence of inflammatory reaction,neuraxial swelling,break and neuronal necrosis in the treatment group was lower than that in the control group(P<0.01～0.005);the variation of incidence of neurofibrillar demyelinating in the treatment group was smaller than that in the control group (P<0.025).The result of ANAE and ALP staining for lymphocytes in the spinal cord from EAE was T-cell.It showed TW could inhibit the allergic action and decrease tissular injury,

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