缺血性脑血管病患者红细胞膜脂区流动性的研究

作者	单位
李其松	上海医科大学神经生物学教研室
汤耀发	上海医科大学神经生物学教研室
马鸿健	上海医科大学神经生物学教研室
施永德	上海医科大学生物物理教研室
秦芝九	上海医科大学神经病学研究所

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中文摘要:

应用荧光偏振光技术对36例瘀症缺血性脑血管病(ICVD)和21例无瘀健康人的红细胞膜脂区微粘度进行比较,并用医学统计多因子逐步回归分析法对36例 ICVD 患者的微粘度与血液系统中16个血浆和全血因子进行相关分析。结果:(1)瘀症 ICVD 患者的红细胞膜脂区微粘度(3.55±0.21泊)明显高于无瘀健康人(2.770±0.12泊),P<0.001。(2)TCVD 患者的红细胞膜脂区微粘度与同时测定的红细胞电泳时间和高密度脂蛋白含量最为相关,前者呈正相关,而后者呈负相关。提示增加红细胞膜表面的流动性和增加高密度脂蛋白的浓度,对防治 ICVD 具有重要意义。

英文摘要:

Measurement of fluidity of erythrocyte membrane(FEM)in thirty-six patients with ischemic cerebral vascular disease(ICVD)by fluorescence polarization of DPH(1,6,-Diphenyl-1,3,5- hexatriene)labelled on lipo-region in intact erythrocyte membrane.Twenty one healthy subjects without any stagnation of blood as control.Also research on coefficient of multiple conrelation among the FEM and other factors in whole blood or plasma by using stepwise multiregression analysis.The results revealed that:(1)FEM of patients with ICVD was 3.55±0.21(),which was significantly higher than that of healthy subjects(2.77±0.12),P<0.001.(2)The FEM of patients with ICVD were positive correlation with RBC electrophoresis rate,whole blood viscosity and low density lipo-proteins and were negative correlation with high density lipo-proteins.These findings suggested that it would be available for preventing ICVD by increasing of the surface charge on erythrocyte and of the high.density lipo-proteins.

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