热毒清对家兔线粒体H~+-ATP合酶活性保护作用的实验研究

作者	单位
梁驹卿	同济医科大学实验医学研究中心
皇甫永穆	同济医科大学实验医学研究中心
李东	同济医科大学实验医学研究中心
李萍	同济医科大学实验医学研究中心
陆付耳	同济医科大学中西医结合研究所
李鸣真	同济医科大学中西医结合研究所
叶望云	同济医科大学中西医结合研究所

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中文摘要:

内毒素制造的家兔全身性 shwartzman 反应模型,肝线粒体 H~+-ATP 合酶活性下降,而热毒清组此酶活性正常,两组间有显著差异(P<0.05)。提示热毒清注射液具有保护线粒体 H~+-ATP 合酶的作用。

英文摘要:

To observe the effect of Re-Du-Qing on the toxic effect of endotoxin,the rabbit model of general Sbwartzman reaction was made by injection of endotoxin into ear vein and the H~+-ATP synthase activities of rabbit liver mitochondria were measured.The results showed that the H~+-ATP synthase activity of endotoxin group was significantly lower than that of the normal group and group which had been simultaneously injected Re-Du-Qing(P<0.05).The tevel of H~+-ATP synthase activity was almost raised to normal value,when Re-Du-Qing or dexamethasone was injected simultaneously with endotoxin respectively.It suggested that Re-Du-Qing was able to alleviate the nocuous effect of endotoxin on H~+-ATP synthase activity in the mitochondria of rabbit liver cells.

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