麻杏石甘汤加味对急性下呼吸道感染患儿免疫功能的影响

以麻杏石甘汤为主治疗小儿急性下呼吸道感染,并测定了患儿外周血OKT⁺细胞、OKT₄⁺细胞、OKT₈⁺细胞、OKL₄⁺/OKT₈⁺细胞比值及血清 IgG,IgA、IgM等7项免疫指标,并对本方进行了动物实验。结果表明:（1）患儿治疗前细胞免疫功能降低,体液免疫功能增强。(2>本方可提高患儿细胞免疫功能,调整 T 淋巴细胞亚群间的比例关系。（3）本方使小白鼠吞噬指数、脾指数、血清溶血素增高,使小白鼠皮肤迟发反应增强。

英文摘要:

This paper reported the effect of Ma-Xin-Shi-Gan tang （Decoction of Herba Ephedrae,Semen Armeniacae Amarum,Radix Glycyrrhizae and Gypsum Fihrosum） on the immune function of the children with acute lower respiratory tract infection （ALRTI）.64 cases of ALRTI children were chosen for clinical observation.Laboratory researches including 7 immune indexes:blood OKT₃⁺ cell,OKT₄⁺ cell,OKT₈⁺ cell and OKT₄⁺/OKT₈⁺ cell ratio,serum IgG,IgA,IgM.Some tests in experimental mice were also made. The results showed:（1）Before treatment,the blood OKT₃⁺ cell,OKT₄⁺ cell and OKT₄⁺/OKT₈⁺ cell ratio of the ALRTI children were lower,OKT₈⁺ cell was higher than that of the normal group, which indicated lowered function of cell mediated immunity （CMI） in ALRTI children.Furthermore, IgM content in serum of the ALRTI children was significantly higher than that of the normal group, which indicated a hyperhumoral immunity （HI）.（2）Blood OKT₄⁺ cell and OKT₄⁺/OKT₈⁺ cell ratio in children after treatment with the Decoction were higher than those before treatment,which suggest- ed the Decoction can regulate the cell ratio of OKT₄⁺ and OKT₈⁺,and relieve the functional inhibition of CMI in ALRTI children,while comparing with the western medicine （WM） group,the blood OKT₃⁺ cell,OKT₄⁺ cell and serum IgG content in the Decoction group after treatment were higher.In the WM group,the serum IgG and IgA contents were lower than those of the normal group, which indicated an inhibited function of HI after treatment.（3）In experimental mice,the Decoction can increase the phagocytic index of the macrophage,the spleen index and the level of hemolysin.It can also enhance the skin delayed allergic reaction of the mice.It,thereby,can enhance the immune function of the experimental mice.（4）The Decoction is a good remedy for children with ALRTI.The time for eliminating cough and wheezing,in the Decoction group was shorter than the WM group.The Decoction’s function of clearing away the heat-evil and eliminating sputum,relieving cough and asthma may be interrelated to its function of enhancing and regulating the function of CMI in ALRTI children.

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