丹参对冠状动脉狭窄时左心室舒张功能的影响

作者	单位
徐洪涛	海军总医院心内科
陈士良	第四军医大学心内科
李兰荪	第四军医大学生理教研室
石湘云	海军总医院心内科

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中文摘要:

在24条麻醉开胸犬上,观察以微米狭窄器造成冠状动脉前降支临界狭窄(冠脉横截面积减少87%)后左室舒张功能的改变及左心房注射丹参注射液后对心肌缺血时心脏 CBF、-dp/dtmax、-Vce、T 值变化的影响。结果表明,冠脉狭窄后,CBF、-dp/dtmax、-Vce 均明显降低(P<0.01),T 值延长,(P<0.01)。而狭窄15min 后左心房注射丹参,可使心肌缺血时左心室舒张功能损害减轻,且以 CBF 的改善在先。

英文摘要:

In 24 open-chest mongrel dogs,coronary artery critical stenosis were produced by a micrometer constriction on left cicumflex coronary artery.It was reduction about 87% in lumen area.CBF,-Vce, -dp/dt max were decreased,T was increased(P<0.01).15 minutes after stenosis,the Salvia miltiorrhiza injection was injected into left atrium.CBF,-dp/dt max,-Vce were increased and T was decreased after the injection of Salvia miltiorrhiza.Moreover,the change of CBF was the earliest. The results proved that the Salvia miltiorrhiza could improve the left ventricular diastolic function in coronary artery stenosis.

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